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    RPL17A ribosomal 60S subunit protein L17A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853674, updated on 13-Apr-2024

    Summary

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    Gene symbol
    RPL17A
    Gene description
    ribosomal 60S subunit protein L17A
    Primary source
    SGD:S000001663
    Locus tag
    YKL180W
    See related
    AllianceGenome:SGD:S000001663
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPL17
    Summary
    A structural constituent of ribosome. Involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit and preribosome, large subunit precursor. Orthologous to several human genes including RPL17-C18orf32 (RPL17-C18orf32 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XI
    Exon count:
    2
    Sequence:
    Chromosome: XI; NC_001143.9 (109269..110129)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tetrafunctional fatty acid synthase subunit FAS1 Neighboring gene ribose phosphate diphosphokinase subunit PRS1 Neighboring gene Coy1p Neighboring gene Ste3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site. Pillet B, et al. PLoS Genet, 2015 Oct. PMID 26447800, Free PMC Article
    2. Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39 of Saccharomyces cerevisiae. Zhang Y, et al. J Biol Chem, 2013 Nov 22. PMID 24072706, Free PMC Article
    3. Dual binding mode of the nascent polypeptide-associated complex reveals a novel universal adapter site on the ribosome. Pech M, et al. J Biol Chem, 2010 Jun 18. PMID 20410297, Free PMC Article
    4. Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly. Micic J, et al. Nat Commun, 2020 Jul 27. PMID 32719344, Free PMC Article
    5. Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps. Saveanu C, et al. EMBO J, 2001 Nov 15. PMID 11707418, Free PMC Article

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our findings indicate that the dedicated chaperone Acl4 accompanies Rpl4 from the cytoplasm to its pre-60S assembly site in the nucleus.
      Title: The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site.
    2. Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39
      Title: Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39 of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L17A
    NP_012741.1
    • Ribosomal 60S subunit protein L17A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      109269..110129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179746.1 → NP_012741.1  TPA: ribosomal 60S subunit protein L17A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012741.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX21, P05740
      UniProtKB/TrEMBL
      A6ZZE6, B3LQS6, C7GJ30, C8ZBZ5, G2WHL3, N1P132
      Conserved Domains (1) summary
      PTZ00178
      Location:1 → 178
      PTZ00178; 60S ribosomal protein L17; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3JCT_P.1
    4V88_BP.1
    4V88_DP.1
    4V8T_P.1
    5APN_P.1
    5APO_P.1
    5FL8_P.1
    5H4P_P.1
    5JCS_P.1
    5T62_c.1
    5T6R_c.1
    5Z3G_T.1
    6ELZ_P.1
    6EM1_P.1
    6EM3_P.1
    6EM4_P.1
    6EM5_P.1
    6FT6_P.1
    6M62_P.1
    6N8J_P.1
    6N8K_P.1
    6N8L_P.1
    6N8M_c.1
    6N8N_c.1
    6N8O_c.1
    7AZY_y.1
    7BT6_P.1
    7BTB_P.1
    7OF1_P.1
    7OH3_P.1
    7OHP_P.1
    7OHQ_P.1
    7OHR_P.1
    7OHS_P.1
    7OHU_P.1
    7OHV_P.1
    7OHW_P.1
    7OHX_P.1
    7OHY_P.1
    P05740.4

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