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    RIE1 Rie1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853165, updated on 13-Apr-2024

    Summary

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    Gene symbol
    RIE1
    Gene description
    Rie1p
    Primary source
    SGD:S000003482
    Locus tag
    YGR250C
    See related
    AllianceGenome:SGD:S000003482
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    WHI8
    Summary
    Enables mRNA binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in cytoplasmic stress granule. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (991176..993521, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene 6-phosphogluconolactonase SOL4 Neighboring gene Mga1p Neighboring gene Nop19p Neighboring gene histone acetyltransferase GCN5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stress granules display bistable dynamics modulated by Cdk. Yahya G, et al. J Cell Biol, 2021 Mar 1. PMID 33480968, Free PMC Article
    2. Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction. Matsui T, et al. PLoS Genet, 2016 Jul. PMID 27437938, Free PMC Article
    3. Analysis of a 17.9 kb region from Saccharomyces cerevisiae chromosome VII reveals the presence of eight open reading frames, including BRF1 (TFIIIB70) and GCN5 genes. Feroli F, et al. Yeast, 1997 Mar 30. PMID 9133742
    4. Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1. Wout PK, et al. Eukaryot Cell, 2009 Jul. PMID 19448108, Free PMC Article
    5. Identification of multi-copy suppressors for endoplasmic reticulum-mitochondria tethering proteins in Saccharomyces cerevisiae. Kojima R, et al. FEBS Lett, 2016 Sep. PMID 27531107

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rie1 and Sgn1 form an RNA-binding complex that enforces the meiotic entry cell fate decision.
      Title: Rie1 and Sgn1 form an RNA-binding complex that enforces the meiotic entry cell fate decision.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rie1p
    NP_011766.3
    • RNA binding protein and negative regulator of START; binds mRNA of the G1 cyclin CLN3 to stress granules for translational repression under conditions of stress; recruits the cyclin-dependent protein kinase Cdc28p to stress granules when stressful conditions are relieved, resulting in the dissolution of the granules, and resumption of translation; localizes to stress granules induced by glucose deprivation; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      991176..993521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181379.3 → NP_011766.3  TPA: Rie1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011766.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV30, P53316
      UniProtKB/TrEMBL
      A0A8H8UKY3, B3LHZ0, B5VJJ1, N1P2N3
      Conserved Domains (2) summary
      TIGR01628
      Location:195 → 757
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12362
      Location:542 → 634
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53316.1

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