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    TPO2 spermine transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853039, updated on 13-Apr-2024

    Summary

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    Gene symbol
    TPO2
    Gene description
    spermine transporter
    Primary source
    SGD:S000003370
    Locus tag
    YGR138C
    See related
    AllianceGenome:SGD:S000003370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables spermine transmembrane transporter activity. Involved in spermine transport. Located in fungal-type vacuole membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (763762..765606, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene proteasome core particle subunit alpha 3 Neighboring gene Lsb1p Neighboring gene Cbf2p Neighboring gene Vps62p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combined roles of exporters in acetic acid tolerance in Saccharomyces cerevisiae. Zhang X, et al. Biotechnol Biofuels Bioprod, 2022 Jun 18. PMID 35717394, Free PMC Article
    2. Upregulation of the Saccharomyces cerevisiae efflux pump Tpo1 rescues an Imp2 transcription factor-deficient mutant from bleomycin toxicity. Berra S, et al. Environ Mol Mutagen, 2014 Jul. PMID 24599794
    3. Quantitative analysis of the modes of growth inhibition by weak organic acids in Saccharomyces cerevisiae. Ullah A, et al. Appl Environ Microbiol, 2012 Dec. PMID 23001666, Free PMC Article
    4. Haa1, a protein homologous to the copper-regulated transcription factor Ace1, is a novel transcriptional activator. Keller G, et al. J Biol Chem, 2001 Oct 19. PMID 11504737
    5. Multiple polyamine transport systems on the vacuolar membrane in yeast. Tomitori H, et al. Biochem J, 2001 Feb 1. PMID 11171066, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spermine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spermine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in spermine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spermine transporter
    NP_011654.1
    • Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      763762..765606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181267.1 → NP_011654.1  TPA: spermine transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011654.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUR9, P53283
      UniProtKB/TrEMBL
      A0A8H4C0K8, A6ZUF1, B3LI91, B5VJ82, C8Z931
      Conserved Domains (1) summary
      cd17323
      Location:173 → 599
      MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53283.1

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