U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TAF6 TATA-binding protein-associated factor TAF6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852766, updated on 13-Apr-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    TAF6
    Gene description
    TATA-binding protein-associated factor TAF6
    Primary source
    SGD:S000003080
    Locus tag
    YGL112C
    See related
    AllianceGenome:SGD:S000003080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TAF60
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and molecular adaptor activity. Involved in several processes, including RNA polymerase II preinitiation complex assembly; histone acetylation; and positive regulation of DNA-templated transcription, initiation. Located in cytosol and nucleus. Part of SAGA complex; SLIK (SAGA-like) complex; and transcription factor TFIID complex. Orthologous to several human genes including TAF6 (TATA-box binding protein associated factor 6). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (298178..299728, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sld3p Neighboring gene ribosome biosynthesis protein NSA1 Neighboring gene Cue3p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Synergistic and promoter-selective activation of transcription by recruitment of transcription factors TFIID and TFIIB. Gonzalez-Couto E, et al. Proc Natl Acad Sci U S A, 1997 Jul 22. PMID 9223310, Free PMC Article
    2. Molecular and genetic characterization of a Taf1p domain essential for yeast TFIID assembly. Singh MV, et al. Mol Cell Biol, 2004 Jun. PMID 15143185, Free PMC Article
    3. Use of a genetically introduced cross-linker to identify interaction sites of acidic activators within native transcription factor IID and SAGA. Klein J, et al. J Biol Chem, 2003 Feb 28. PMID 12501245
    4. A histone fold TAF octamer within the yeast TFIID transcriptional coactivator. Selleck W, et al. Nat Struct Biol, 2001 Aug. PMID 11473260
    5. Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation. Reeves WM, et al. Mol Cell Biol, 2003 Jan. PMID 12482986, Free PMC Article

    See all (142) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that HEAT domain and the histone H4-like histone-fold domain (HFD) in TAF6 are required for transcriptional activation.
      Title: Mutational analysis of TAF6 revealed the essential requirement of the histone-fold domain and the HEAT repeat domain for transcriptional activation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SLIK (SAGA-like) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SLIK (SAGA-like) complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    TATA-binding protein-associated factor TAF6
    NP_011403.1
    • Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      298178..299728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180977.1 → NP_011403.1  TPA: TATA-binding protein-associated factor TAF6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011403.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU35, P53040
      UniProtKB/TrEMBL
      A0A6A5PY20, A6ZU70, B3LHH5, C7GM06, C8Z8D8, N1P9P2
      Conserved Domains (1) summary
      COG5095
      Location:6 → 513
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6T9I_E.1
    6T9K_E.1
    P53040.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous