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    PDR15 ATP-binding cassette multidrug transporter PDR15 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852015, updated on 13-Apr-2024

    Summary

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    Gene symbol
    PDR15
    Gene description
    ATP-binding cassette multidrug transporter PDR15
    Primary source
    SGD:S000002814
    Locus tag
    YDR406W
    See related
    AllianceGenome:SGD:S000002814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in response to xenobiotic stimulus. Located in cell periphery. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to several human genes including ABCA10 (ATP binding cassette subfamily A member 10); ABCA3 (ATP binding cassette subfamily A member 3); and ABCA5 (ATP binding cassette subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1279210..1283799)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II subunit RPB7 Neighboring gene mitochondrial 54S ribosomal protein YmL41 Neighboring gene Trs120p Neighboring gene phosphoribosylglycinamide formyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast. Hikkel I, et al. J Biol Chem, 2003 Mar 28. PMID 12529331
    2. Key cytomembrane ABC transporters of Saccharomyces cerevisiae fail to improve the tolerance to D-limonene. Hu F, et al. Biotechnol Lett, 2012 Aug. PMID 22526424
    3. The yeast Pdr15p ATP-binding cassette (ABC) protein is a general stress response factor implicated in cellular detoxification. Wolfger H, et al. J Biol Chem, 2004 Mar 19. PMID 14699125
    4. Transcriptome response to alkane biofuels in Saccharomyces cerevisiae: identification of efflux pumps involved in alkane tolerance. Ling H, et al. Biotechnol Biofuels, 2013 Jul 5. PMID 23826995, Free PMC Article
    5. The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. Wolfger H, et al. FEBS Lett, 1997 Dec 1. PMID 9428726

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette multidrug transporter PDR15
    NP_010694.1
    • Plasma membrane ATP binding cassette (ABC) transporter; multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element; PDR15 has a paralog, PDR5, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1279210..1283799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180714.1 → NP_010694.1  TPA: ATP-binding cassette multidrug transporter PDR15 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010694.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT38, Q04182
      UniProtKB/TrEMBL
      A0A8H8UNV0, C8Z5W9, N1P7E2
      Conserved Domains (2) summary
      TIGR00956
      Location:110 → 1518
      3a01205; Pleiotropic Drug Resistance (PDR) Family protein
      pfam14510
      Location:47 → 162
      ABC_trans_N; ABC-transporter extracellular N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04182.1

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