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    MTF2 Mtf2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851517, updated on 13-Apr-2024

    Summary

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    Gene symbol
    MTF2
    Gene description
    Mtf2p
    Primary source
    SGD:S000002202
    Locus tag
    YDL044C
    See related
    AllianceGenome:SGD:S000002202
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NAM1
    Summary
    Enables RNA binding activity. Involved in mRNA processing and mitochondrial translation. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (373967..375289, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein YmS-T Neighboring gene FMN adenylyltransferase Neighboring gene Prp11p Neighboring gene NAD-dependent histone deacetylase SIR2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NAM1/MTF2 nuclear gene product is selectively required for the stability and/or processing of mitochondrial transcripts of the atp6 and of the mosaic, cox1 and cytb genes in Saccharomyces cerevisiae. Groudinsky O, et al. Mol Gen Genet, 1993 Sep. PMID 8413192
    2. The NAM1 protein (NAM1p), which is selectively required for cox1, cytb and atp6 transcript processing/stabilisation, is located in the yeast mitochondrial matrix. Wallis MG, et al. Eur J Biochem, 1994 May 15. PMID 8200349
    3. Molecular analysis of the mitochondrial transcription factor mtf2 of Saccharomyces cerevisiae. Lisowsky T. Mol Gen Genet, 1990 Jan. PMID 2183001
    4. Change of serine309 into proline causes temperature sensitivity of the nuclear NAM1/MTF2 gene product for yeast mitochondria. Lisowsky T, et al. Nucleic Acids Res, 1990 Dec 11. PMID 2124681, Free PMC Article
    5. Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. Rodeheffer MS, et al. J Biol Chem, 2001 Mar 16. PMID 11118450, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mtf2p
    NP_010240.1
    • Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      373967..375289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180103.1 → NP_010240.1  TPA: Mtf2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010240.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRV2, P10849, Q05430
      UniProtKB/TrEMBL
      A0A8H8UMN7, B3LGU2, C7GPW3, C8Z4M6, N1P641
      Conserved Domains (1) summary
      pfam19189
      Location:211 → 434
      Mtf2; Mtf2 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10849.1

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