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    PCL2 cyclin PCL2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851430, updated on 25-Apr-2024

    Summary

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    Gene symbol
    PCL2
    Gene description
    cyclin PCL2
    Primary source
    SGD:S000002285
    Locus tag
    YDL127W
    See related
    AllianceGenome:SGD:S000002285
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CLN4
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of establishment or maintenance of cell polarity; and septin ring organization. Located in cellular bud neck; cellular bud tip; and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex and incipient cellular bud site. Orthologous to human CNPPD1 (cyclin Pas1/PHO80 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (234927..235853)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Vcx1p Neighboring gene AAA family ATPase CDC48 Neighboring gene adenosine 5'-monophosphoramidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PCL2 (ORFD)-PHO85 cyclin-dependent kinase complex: a cell cycle regulator in yeast. Measday V, et al. Science, 1994 Nov 25. PMID 7973731
    2. The GTPase-activating protein Rga1 interacts with Rho3 GTPase and may regulate its function in polarized growth in budding yeast. He F, et al. PLoS One, 2015. PMID 25860339, Free PMC Article
    3. Uncovering genetic relationships using small molecules that selectively target yeast cell cycle mutants. Nehil MT, et al. Chem Biol Drug Des, 2007 Apr. PMID 17461973
    4. Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4. Baetz K, et al. Mol Cell Biol, 2001 Oct. PMID 11533240, Free PMC Article
    5. Interaction of yeast Rvs167 and Pho85 cyclin-dependent kinase complexes may link the cell cycle to the actin cytoskeleton. Lee J, et al. Curr Biol, 1998 Dec 3. PMID 9843683

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of establishment or maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of cell polarity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in septin ring organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclin PCL2
    NP_010156.2
    • Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth; PCL2 has a paralog, PCL9, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      234927..235853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180186.1 → NP_010156.2  TPA: cyclin PCL2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010156.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRM3, P25693, Q07554
      UniProtKB/TrEMBL
      A0A6A5PYZ6, A6ZXK2, B3LH17, B5VFE2, C7GJI9, C8Z6H6, G2WC35, N1P403
      Conserved Domains (1) summary
      cd20557
      Location:48 → 143
      CYCLIN_ScPCL1-like; cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25693.2

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