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    SRF1 Srf1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851423, updated on 11-Apr-2024

    Summary

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    Gene symbol
    SRF1
    Gene description
    Srf1p
    Primary source
    SGD:S000002291
    Locus tag
    YDL133W
    See related
    AllianceGenome:SGD:S000002291
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in positive regulation of catalytic activity. Located in cell periphery and fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (222427..223740)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene phosphoprotein phosphatase 2A catalytic subunit PPH21 Neighboring gene ribosomal 60S subunit protein L41B Neighboring gene cullin CDC53 Neighboring gene homocitrate synthase LYS21

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor. Kennedy MA, et al. PLoS Genet, 2011 Feb 10. PMID 21347278, Free PMC Article
    2. Fig1p facilitates Ca2+ influx and cell fusion during mating of Saccharomyces cerevisiae. Muller EM, et al. J Biol Chem, 2003 Oct 3. PMID 12878605
    3. The oxysterol binding protein Kes1p regulates Golgi apparatus phosphatidylinositol-4-phosphate function. Fairn GD, et al. Proc Natl Acad Sci U S A, 2007 Sep 25. PMID 17881569, Free PMC Article
    4. Saccharomyces cerevisiae S288C genome annotation: a working hypothesis. Fisk DG, et al. Yeast, 2006 Sep. PMID 17001629, Free PMC Article
    5. A nuclear role for the DEAD-box protein Dbp5 in tRNA export. Lari A, et al. Elife, 2019 Aug 27. PMID 31453808, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of YDL133w, a previously uncharacterized gene here renamed SRF1 (Spo14 Regulatory Factor 1), resulted in the greatest differential sensitivity to C16:0 PAF over C16:0 lyso-PAF.
      Title: Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of catalytic activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Srf1p
    NP_010149.1
    • Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      222427..223740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180192.1 → NP_010149.1  TPA: Srf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010149.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRL6, P89897, Q12516, Q7LGS2
      UniProtKB/TrEMBL
      A0A6A5PXY6, A6ZXJ5, B5VFD7, C7GSS8, G2WC28, N1P7J2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12516.1

    Gene LinkOut

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