GUD1 guanine deaminase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: GUD1
Gene description: guanine deaminase
Primary source: SGD:S000002397
Locus tag: YDL238C
See related: AllianceGenome:SGD:S000002397
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables guanine deaminase activity. Involved in guanine catabolic process. Located in cytoplasm. Orthologous to human GDA (guanine deaminase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (28985..30454, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

amino acid sequence of enzyme expressed during post-diauxic growth
Title: GUD1 (YDL238c) encodes Saccharomyces cerevisiae guanine deaminase, an enzyme expressed during post-diauxic growth.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables guanine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanine deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanine deaminase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in guanine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in guanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in guanine metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanine deaminase

NP_010043.1

EC 3.5.4.3

Guanine deaminase; a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

28985..30454 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180298.1 → NP_010043.1 TPA: guanine deaminase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010043.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRB8, Q07729

UniProtKB/TrEMBL

A0A8H8UM66, B3LHB4, B5VF43, C7GJQ7, N1P5Z7

Conserved Domains (1) summary

cd01303
Location:21 → 483

GDEase; Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and ...