The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference ARS-UCD2.0 Primary Assembly

Genomic

1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

   Range

   22826288..23055066

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_003586275.6 → XP_003586323.2  rap guanine nucleotide exchange factor 6 isoform X1

   UniProtKB/TrEMBL

   F1MS53

   Related

   ENSBTAP00000058761.2, ENSBTAT00000083549.2

   Conserved Domains (6) summary

   smart00229
   Location:412 → 525

   RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

   cd00038
   Location:280 → 380

   CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

   cd00155
   Location:857 → 1081

   RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

   cd00992
   Location:529 → 609

   PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

   cl00047
   Location:37 → 82

   CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

   cl00155
   Location:749 → 833

   UBQ; Ubiquitin-like proteins

2. XM_002688965.7 → XP_002689011.3  rap guanine nucleotide exchange factor 6 isoform X2

   UniProtKB/TrEMBL

   F1MS53

   Related

   ENSBTAP00000075230.1, ENSBTAT00000104653.1

   Conserved Domains (6) summary

   smart00229
   Location:412 → 525

   RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

   cd00038
   Location:280 → 380

   CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

   cd00155
   Location:857 → 1067

   RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

   cd00992
   Location:529 → 609

   PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

   cl00047
   Location:37 → 82

   CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

   cl00155
   Location:749 → 833

   UBQ; Ubiquitin-like proteins

3. XM_024995044.2 → XP_024850812.1  rap guanine nucleotide exchange factor 6 isoform X3

   UniProtKB/TrEMBL

   A0A3Q1LY57, F1MS53

   Related

   ENSBTAP00000060550.2, ENSBTAT00000070892.2

   Conserved Domains (5) summary

   smart00229
   Location:384 → 497

   RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

   cd00038
   Location:252 → 352

   CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

   cd00155
   Location:829 → 1053

   RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

   cd00992
   Location:501 → 581

   PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

   cl00155
   Location:721 → 805

   UBQ; Ubiquitin-like proteins

4. XM_024995048.2 → XP_024850816.1  rap guanine nucleotide exchange factor 6 isoform X6

   UniProtKB/TrEMBL

   A0A3Q1N8B9

   Related

   ENSBTAP00000102319.1, ENSBTAT00000129447.1

   Conserved Domains (6) summary

   smart00229
   Location:412 → 525

   RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

   cd00038
   Location:280 → 380

   CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

   cd00155
   Location:857 → 1081

   RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

   cd00992
   Location:529 → 609

   PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

   cl00047
   Location:37 → 82

   CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

   cl00155
   Location:749 → 833

   UBQ; Ubiquitin-like proteins

5. XM_024995049.2 → XP_024850817.1  rap guanine nucleotide exchange factor 6 isoform X7

   UniProtKB/TrEMBL

   A0A3Q1N8B9

   Conserved Domains (6) summary

   smart00229
   Location:412 → 525

   RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

   cd00038
   Location:280 → 380

   CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

   cd00155
   Location:857 → 1067

   RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

   cd00992
   Location:529 → 609

   PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

   cl00047
   Location:37 → 82

   CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

   cl00155
   Location:749 → 833

   UBQ; Ubiquitin-like proteins

6. XM_015472120.3 → XP_015327606.2  rap guanine nucleotide exchange factor 6 isoform X4

   UniProtKB/TrEMBL

   A0A3Q1MMY7

   Related

   ENSBTAP00000060828.2, ENSBTAT00000066392.2

   Conserved Domains (5) summary

   smart00229
   Location:317 → 430

   RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

   cd00038
   Location:185 → 285

   CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

   cd00155
   Location:762 → 986

   RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

   cd00992
   Location:434 → 514

   PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

   cl00155
   Location:654 → 738

   UBQ; Ubiquitin-like proteins

7. XM_005209079.5 → XP_005209136.2  rap guanine nucleotide exchange factor 6 isoform X5

   UniProtKB/TrEMBL

   A0A3Q1MMY7, A0A3Q1MUH1

   Conserved Domains (5) summary

   smart00229
   Location:265 → 378

   RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

   cd00038
   Location:133 → 233

   CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

   cd00155
   Location:710 → 934

   RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

   cd00992
   Location:382 → 462

   PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

   cl00155
   Location:602 → 686

   UBQ; Ubiquitin-like proteins