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    SLC12A4 solute carrier family 12 member 4 [ Bos taurus (cattle) ]

    Gene ID: 533876, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SLC12A4provided by VGNC
    Official Full Name
    solute carrier family 12 member 4provided by VGNC
    Primary source
    VGNC:VGNC:34667
    See related
    Ensembl:ENSBTAG00000018045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 18
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (35425222..35447068, complement)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene protein serine kinase H1 Neighboring gene proteasome 20S subunit beta 10 Neighboring gene lecithin-cholesterol acyltransferase Neighboring gene dipeptidase 3 Neighboring gene dipeptidase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Noncanonical and canonical splice sites: a novel mutation at the rare noncanonical splice-donor cut site (IVS4+1A>G) of SEDL causes variable splicing isoforms in X-linked spondyloepiphyseal dysplasia tarda. Xiong F, et al. Eur J Hum Genet, 2009 Apr. PMID 19002213, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables potassium:chloride symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chloride ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 12 member 4
    Names
    solute carrier family 12 (potassium/chloride transporters), member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001174091.1 → NP_001167562.1  solute carrier family 12 member 4

      Status: VALIDATED

      Source sequence(s)
      AM028258, CK944300, DN532548, DT809308, DV815337, EE346647, EE915011
      UniProtKB/TrEMBL
      E1BCI8
      Conserved Domains (3) summary
      TIGR00930
      Location:42 → 1086
      2a30; K-Cl cotransporter
      pfam03522
      Location:709 → 1086
      SLC12; Solute carrier family 12
      cl00456
      Location:142 → 303
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      35425222..35447068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059876816.1 → XP_059732799.1  solute carrier family 12 member 4 isoform X1

      Related
      ENSBTAP00000024019.6, ENSBTAT00000024019.7

    2. XM_059876817.1 → XP_059732800.1  solute carrier family 12 member 4 isoform X2

      Related
      ENSBTAP00000082214.1, ENSBTAT00000091229.1

    3. XM_059876818.1 → XP_059732801.1  solute carrier family 12 member 4 isoform X3

    4. XM_059876819.1 → XP_059732802.1  solute carrier family 12 member 4 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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