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    ATP7B ATPase copper transporting beta [ Bos taurus (cattle) ]

    Gene ID: 518075, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ATP7Bprovided by VGNC
    Official Full Name
    ATPase copper transporting betaprovided by VGNC
    Primary source
    VGNC:VGNC:26328
    See related
    BGD:BT12155; Ensembl:ENSBTAG00000010353
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (21341015..21415269, complement)

    Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346743 Neighboring gene coiled-coil domain containing 70 Neighboring gene ALG11 alpha-1,2-mannosyltransferase Neighboring gene NIMA related kinase 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables P-type divalent copper transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in copper ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    copper-transporting ATPase 2
    XP_002691840.1
    XP_005213777.1
    XP_005213778.1
    XP_005213779.1
    XP_059748203.1
    XP_059748204.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      21341015..21415269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005213721.5 → XP_005213778.1  copper-transporting ATPase 2 isoform X3

      See identical proteins and their annotated locations for XP_005213778.1

      UniProtKB/TrEMBL
      A0A3Q1MGR1
      Conserved Domains (4) summary
      COG2217
      Location:546 → 1334
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:1169 → 1288
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:140 → 202
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:748 → 995
      E1-E2_ATPase; E1-E2 ATPase

    2. XM_005213720.5 → XP_005213777.1  copper-transporting ATPase 2 isoform X3

      See identical proteins and their annotated locations for XP_005213777.1

      UniProtKB/TrEMBL
      A0A3Q1MGR1
      Related
      ENSBTAP00000056722.2, ENSBTAT00000068750.2
      Conserved Domains (4) summary
      COG2217
      Location:546 → 1334
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:1169 → 1288
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:140 → 202
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:748 → 995
      E1-E2_ATPase; E1-E2 ATPase

    3. XM_005213722.5 → XP_005213779.1  copper-transporting ATPase 2 isoform X3

      See identical proteins and their annotated locations for XP_005213779.1

      UniProtKB/TrEMBL
      A0A3Q1MGR1
      Conserved Domains (4) summary
      COG2217
      Location:546 → 1334
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:1169 → 1288
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:140 → 202
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:748 → 995
      E1-E2_ATPase; E1-E2 ATPase

    4. XM_059892220.1 → XP_059748203.1  copper-transporting ATPase 2 isoform X2

    5. XM_002691794.7 → XP_002691840.1  copper-transporting ATPase 2 isoform X1

      See identical proteins and their annotated locations for XP_002691840.1

      UniProtKB/TrEMBL
      A0A3Q1MGR1, F1MKI1
      Related
      ENSBTAP00000013674.5, ENSBTAT00000013674.7
      Conserved Domains (4) summary
      COG2217
      Location:607 → 1395
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:1230 → 1349
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:201 → 263
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:809 → 1056
      E1-E2_ATPase; E1-E2 ATPase

    6. XM_059892221.1 → XP_059748204.1  copper-transporting ATPase 2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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