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    C1R complement C1r [ Bos taurus (cattle) ]

    Gene ID: 511581, updated on 5-Mar-2024

    Summary

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    Official Symbol
    C1Rprovided by VGNC
    Official Full Name
    complement C1rprovided by VGNC
    Primary source
    VGNC:VGNC:56194
    See related
    BGD:BT20853; Ensembl:ENSBTAG00000008612
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (103376575..103387592)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like Neighboring gene uncharacterized LOC101902570 Neighboring gene uncharacterized LOC112446757 Neighboring gene complement C1s Neighboring gene lysophosphatidylcholine acyltransferase 3 Neighboring gene EMG1 N1-specific pseudouridine methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium. Ying G, et al. J Biol Chem, 2018 Nov 9. PMID 30228185, Free PMC Article
    2. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC127774

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in complement activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in zymogen activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in blood microparticle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    complement C1r subcomponent
    Names
    complement component 1, r subcomponent
    NP_001029579.1
    XP_005207185.1
    XP_059742284.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034407.1 → NP_001029579.1  complement C1r subcomponent precursor

      See identical proteins and their annotated locations for NP_001029579.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103405
      UniProtKB/TrEMBL
      F1N0N3, Q3SYT3
      Conserved Domains (3) summary
      smart00042
      Location:27 → 138
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      pfam00431
      Location:193 → 302
      CUB; CUB domain
      pfam14670
      Location:160 → 189
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      103376575..103387592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005207128.4 → XP_005207185.1  complement C1r subcomponent isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MGP1
      Related
      ENSBTAP00000069754.2, ENSBTAT00000073935.2
      Conserved Domains (6) summary
      smart00020
      Location:471 → 705
      Tryp_SPc; Trypsin-like serine protease
      smart00042
      Location:35 → 146
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      cd00190
      Location:472 → 708
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00084
      Location:317 → 379
      Sushi; Sushi repeat (SCR repeat)
      pfam00431
      Location:201 → 310
      CUB; CUB domain
      pfam14670
      Location:168 → 197
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_059886301.1 → XP_059742284.1  complement C1r subcomponent isoform X2

      UniProtKB/TrEMBL
      A5D9E9
      Related
      ENSBTAP00000011362.4, ENSBTAT00000011362.5
    Nucleotide Protein Strain
    Heading Accession and Version

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