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    bgm bubblegum [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44117, updated on 10-May-2024

    Summary

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    Official Symbol
    bgmprovided by FlyBase
    Official Full Name
    bubblegumprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027348
    Locus tag
    Dmel_CG4501
    See related
    AllianceGenome:FB:FBgn0027348
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2a9hom; BG:DS01514.2; BG:DS0514.2; Bgm; CG4501; Dmel\CG4501
    Summary
    Enables long-chain fatty acid-CoA ligase activity. Involved in several processes, including long-chain fatty acid metabolic process; neuron cellular homeostasis; and positive regulation of circadian sleep/wake cycle, sleep. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; extended germ band embryo; and fat body. Used to study adrenoleukodystrophy. Orthologous to several human genes including ACSBG2 (acyl-CoA synthetase bubblegum family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See bgm in Genome Data Viewer
    Location:
    34F1-34F1; 2-50 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14013004..14019328)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14013004..14019328)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Glutamine-CTG 4-1 Neighboring gene antisense RNA:CR44849 Neighboring gene Nimrod C3 Neighboring gene long non-coding RNA:CR45352

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutant fruit flies respond to Lorenzo's oil. Barinaga M. Science, 1999 Jun 18. PMID 10400528
    2. Preventing neurodegeneration in the Drosophila mutant bubblegum. Min KT, et al. Science, 1999 Jun 18. PMID 10373116
    3. Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases. Sivachenko A, et al. Dis Model Mech, 2016 Apr. PMID 26893370, Free PMC Article
    4. The acyl-CoA Synthetase, pudgy, Promotes Sleep and Is Required for the Homeostatic Response to Sleep Deprivation. Thimgan MS, et al. Front Endocrinol (Lausanne), 2018. PMID 30186232, Free PMC Article
    5. Etiology and treatment of adrenoleukodystrophy: new insights from Drosophila. Gordon HB, et al. Dis Model Mech, 2018 Jun 15. PMID 29739804, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fatty acid ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress HMP PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bubblegum
    Names
    CG4501-PA
    CG4501-PC
    bgm-PA
    bgm-PC
    NP_001285923.1
    NP_524698.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14013004..14019328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298994.1 → NP_001285923.1  bubblegum, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285923.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MT84, Q9V3S9
      UniProtKB/TrEMBL
      B5RIV0
      Conserved Domains (2) summary
      cd05933
      Location:69 → 665
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
      COG1022
      Location:32 → 666
      FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]

    2. NM_079959.4 → NP_524698.1  bubblegum, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524698.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MT84, Q9V3S9
      UniProtKB/TrEMBL
      B5RIV0
      Related
      FBpp0080167
      Conserved Domains (2) summary
      cd05933
      Location:69 → 665
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
      COG1022
      Location:32 → 666
      FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5RIV0 B5RIV0
    Q9V3S9.1 Q9V3S9

    Gene LinkOut

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