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    CG1275 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38286, updated on 26-Apr-2024

    Summary

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    Official Symbol
    CG1275provided by FlyBase
    Primary source
    FLYBASE:FBgn0035321
    Locus tag
    Dmel_CG1275
    See related
    AllianceGenome:FB:FBgn0035321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.260; Cyt-b561-1; Dmel\CG1275
    Summary
    Predicted to enable transmembrane ascorbate ferrireductase activity. Predicted to be located in late endosome membrane and lysosomal membrane. Is expressed in adult head; adult heart; embryonic/larval central nervous system; l-LNv neurons; and organism. Orthologous to several human genes including CYBRD1 (cytochrome b reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    62D4-62D4; 3-2 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2252744..2257423, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2252744..2257423, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Elongator complex protein 5 Neighboring gene peptide O-xylosyltransferase Neighboring gene uncharacterized protein Neighboring gene ecdysoneless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular physiology of iron trafficking in Drosophila melanogaster. Wu S, et al. Curr Opin Insect Sci, 2022 Apr. PMID 35158107
    2. Iron homeostasis in insects: Insights from Drosophila studies. Tang X, et al. IUBMB Life, 2013 Oct. PMID 24078394
    3. Molecular organization of Drosophila neuroendocrine cells by Dimmed. Park D, et al. Curr Biol, 2011 Sep 27. PMID 21885285, Free PMC Article
    4. Metal-metal interaction and metal toxicity: a comparison between mammalian and D. melanogaster. Yu X, et al. Xenobiotica, 2021 Jul. PMID 33929283
    5. Iron absorption in Drosophila melanogaster. Mandilaras K, et al. Nutrients, 2013 May 17. PMID 23686013, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane ascorbate ferrireductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1275-PA
    CG1275-PB
    CG1275-PC
    CG1275-PD
    DcytB-like
    cytochrome [[b561-1]]
    NP_647703.1
    NP_728726.1
    NP_728727.1
    NP_995963.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2252744..2257423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206241.3 → NP_995963.1  uncharacterized protein Dmel_CG1275, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995963.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KV99
      Conserved Domains (1) summary
      cd08764
      Location:23 → 239
      Cyt_b561_CG1275_like; Non-vertebrate eumetazoan cytochrome b(561)

    2. NM_139446.4 → NP_647703.1  uncharacterized protein Dmel_CG1275, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647703.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7U1
      Related
      FBpp0072783
      Conserved Domains (1) summary
      cd08764
      Location:120 → 336
      Cyt_b561_CG1275_like; Non-vertebrate eumetazoan cytochrome b(561)

    3. NM_167942.3 → NP_728727.1  uncharacterized protein Dmel_CG1275, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728727.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7U1
      Related
      FBpp0072785
      Conserved Domains (1) summary
      cd08764
      Location:120 → 336
      Cyt_b561_CG1275_like; Non-vertebrate eumetazoan cytochrome b(561)

    4. NM_167941.3 → NP_728726.1  uncharacterized protein Dmel_CG1275, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728726.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7U2
      Related
      FBpp0072784
      Conserved Domains (1) summary
      cd08764
      Location:34 → 250
      Cyt_b561_CG1275_like; Non-vertebrate eumetazoan cytochrome b(561)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KV99 Q7KV99
    Q9I7U1 Q9I7U1
    Q9I7U2 Q9I7U2

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