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    GPR17 G protein-coupled receptor 17 [ Homo sapiens (human) ]

    Gene ID: 2840, updated on 11-Apr-2024

    Summary

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    Official Symbol
    GPR17provided by HGNC
    Official Full Name
    G protein-coupled receptor 17provided by HGNC
    Primary source
    HGNC:HGNC:4471
    See related
    Ensembl:ENSG00000144230 MIM:603071; AllianceGenome:HGNC:4471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within negative regulation of inflammatory response to antigenic stimulus. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 16.2), endometrium (RPKM 2.8) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2q14.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (127646153..127652639)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (128081407..128087893)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128403728..128410213)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373609 Neighboring gene myosin VIIB Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128335179-128335732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16497 Neighboring gene uncharacterized LOC101927834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128393428-128394374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128394375-128395321 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128395322-128396268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128396269-128397214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128406535-128407262 Neighboring gene Sharpr-MPRA regulatory region 7437 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128407989-128408715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128408716-128409441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128416288-128416788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128419363-128420360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128420398-128420938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128420939-128421478 Neighboring gene LIM zinc finger domain containing 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:128457593-128458792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11936 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:128478937-128480136 Neighboring gene SFT2 domain containing 3 Neighboring gene WD repeat domain 33 Neighboring gene MPRA-validated peak3854 silencer Neighboring gene MPRA-validated peak3855 silencer Neighboring gene MPRA-validated peak3856 silencer Neighboring gene MPRA-validated peak3857 silencer Neighboring gene RNY4 pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of human G-protein-coupled receptor 17 ligand binding sites. Konda Mani S, et al. J Cell Biochem, 2023 Apr. PMID 36791278
    2. GPR17 signaling activation by CHBC agonist induced cell death via modulation of MAPK pathway in glioblastoma. Nguyen P, et al. Life Sci, 2022 Feb 15. PMID 35016881
    3. Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles. Conley JM, et al. J Biol Chem, 2021 Jul. PMID 34144038, Free PMC Article
    4. G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production. Liu H, et al. Cell Death Dis, 2021 Jun 12. PMID 34120140, Free PMC Article
    5. The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients. Angelini J, et al. Int J Mol Sci, 2021 Apr 27. PMID 33925469, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural analysis of human G-protein-coupled receptor 17 ligand binding sites.
      Title: Structural analysis of human G-protein-coupled receptor 17 ligand binding sites.
    2. Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication.
      Title: Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication.
    3. Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells.
      Title: Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells.
    4. GPR17 signaling activation by CHBC agonist induced cell death via modulation of MAPK pathway in glioblastoma.
      Title: GPR17 signaling activation by CHBC agonist induced cell death via modulation of MAPK pathway in glioblastoma.
    5. Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis.
      Title: Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis.
    6. G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production.
      Title: G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production.
    7. Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles.
      Title: Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles.
    8. The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients.
      Title: The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients.
    9. FLIM-FRET-Based Structural Characterization of a Class-A GPCR Dimer in the Cell Membrane.
      Title: FLIM-FRET-Based Structural Characterization of a Class-A GPCR Dimer in the Cell Membrane.
    10. GPR17 may mediate hypoxia injury in RGC-5 cells, while the knockdown of GPR17 can reduce the hypoxia injury
      Title: [G protein-coupled receptor 17 is involved in CoCl(2)-induced hypoxic injury in RGC-5 cells].
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686M18273

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemokine receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables receptor serine/threonine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    uracil nucleotide/cysteinyl leukotriene receptor
    Names
    P2Y-like receptor
    R12
    UDP/CysLT receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161415.2 → NP_001154887.1  uracil nucleotide/cysteinyl leukotriene receptor isoform a

      See identical proteins and their annotated locations for NP_001154887.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      BC039595, DA314295, DA366480
      Consensus CDS
      CCDS2148.1
      UniProtKB/Swiss-Prot
      A8K9L0, B2R9X0, Q13304, Q8N5S7, Q9UDZ6, Q9UE21
      UniProtKB/TrEMBL
      B3KX68
      Related
      ENSP00000442982.1, ENST00000544369.5
      Conserved Domains (1) summary
      cd15161
      Location:60 → 336
      7tmA_GPR17; G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001161416.2 → NP_001154888.1  uracil nucleotide/cysteinyl leukotriene receptor isoform b

      See identical proteins and their annotated locations for NP_001154888.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      BC039595, DA366480
      Consensus CDS
      CCDS92862.1
      UniProtKB/TrEMBL
      B3KX68, G4XH68
      Conserved Domains (1) summary
      pfam00001
      Location:48 → 297
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_001161417.2 → NP_001154889.1  uracil nucleotide/cysteinyl leukotriene receptor isoform b

      See identical proteins and their annotated locations for NP_001154889.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AK292725, BC039595
      Consensus CDS
      CCDS92862.1
      UniProtKB/TrEMBL
      B3KX68, G4XH68
      Related
      ENSP00000508383.1, ENST00000486700.2
      Conserved Domains (1) summary
      pfam00001
      Location:48 → 297
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    4. NM_005291.3 → NP_005282.1  uracil nucleotide/cysteinyl leukotriene receptor isoform a

      See identical proteins and their annotated locations for NP_005282.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      BC039595, DA390892, Y12546
      Consensus CDS
      CCDS2148.1
      UniProtKB/Swiss-Prot
      A8K9L0, B2R9X0, Q13304, Q8N5S7, Q9UDZ6, Q9UE21
      UniProtKB/TrEMBL
      B3KX68
      Related
      ENSP00000272644.3, ENST00000272644.7
      Conserved Domains (1) summary
      cd15161
      Location:60 → 336
      7tmA_GPR17; G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      127646153..127652639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      128081407..128087893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13304.2 GenPept UniProtKB/Swiss-Prot:Q13304

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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