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    ZNF197 zinc finger protein 197 [ Homo sapiens (human) ]

    Gene ID: 10168, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF197provided by HGNC
    Official Full Name
    zinc finger protein 197provided by HGNC
    Primary source
    HGNC:HGNC:12988
    See related
    Ensembl:ENSG00000186448 MIM:618359; AllianceGenome:HGNC:12988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P18; VHLaK; ZNF20; ZNF166; ZKSCAN9; ZSCAN41; D3S1363E
    Summary
    This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Naturally-occurring readthrough transcription is observed between this gene and the upstream zinc finger protein 660 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017]
    Expression
    Ubiquitous expression in thyroid (RPKM 4.1), ovary (RPKM 3.4) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    3p21.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44625036..44648471)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44640750..44664179)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44666528..44689963)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ZKSCAN7 ZNF cluster antisense RNA 1 Neighboring gene ZNF660-ZNF197 readthrough Neighboring gene zinc finger protein 660 Neighboring gene ZNF197 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44666861-44667363 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44689909-44690468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19768 Neighboring gene zinc finger protein 35 Neighboring gene zinc finger protein 251 pseudogene Neighboring gene zinc finger protein OZF-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19769

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region. Pengue G, et al. Hum Mol Genet, 1993 Jun. PMID 8353497
    2. Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. Gonsky R, et al. Nucleic Acids Res, 1997 Oct 1. PMID 9380504, Free PMC Article
    3. Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. Calabrò V, et al. Hum Genet, 1995 Jan. PMID 7814019
    4. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. Li Z, et al. EMBO J, 2003 Apr 15. PMID 12682018, Free PMC Article
    5. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Camargo LM, et al. Mol Psychiatry, 2007 Jan. PMID 17043677

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough ZNF660-ZNF197

    Readthrough gene: ZNF660-ZNF197, Included gene: ZNF660

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 197
    Names
    VHL-associated KRAB-A domain-containing protein
    pVHL-associated KRAB domain-containing protein
    zinc finger protein 166
    zinc finger protein 20
    zinc finger protein with KRAB and SCAN domains 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024855.3 → NP_001020026.1  zinc finger protein 197 isoform 2

      See identical proteins and their annotated locations for NP_001020026.1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 2 and 4 encode the same isoform (2).
      Source sequence(s)
      AY074878, AY279353
      UniProtKB/Swiss-Prot
      O14709
      Related
      ENSP00000373251.2, ENST00000383745.6
      Conserved Domains (2) summary
      smart00431
      Location:38 → 150
      SCAN; leucine rich region
      pfam01352
      Location:216 → 257
      KRAB; KRAB box

    2. NM_001323293.2 → NP_001310222.1  zinc finger protein 197 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC099669, BQ002665
      UniProtKB/Swiss-Prot
      B2RAH8, O14709, Q86VG0
      Related
      ENSP00000379370.1, ENST00000396058.1
      Conserved Domains (5) summary
      smart00431
      Location:38 → 150
      SCAN; leucine rich region
      COG5048
      Location:424 → 853
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:400 → 420
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:216 → 256
      KRAB; KRAB box
      pfam13465
      Location:384 → 409
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001323294.2 → NP_001310223.1  zinc finger protein 197 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: Variants 2 and 4 encode the same isoform (2).
      Source sequence(s)
      AC099669, AY279353, BQ002665
      UniProtKB/Swiss-Prot
      O14709
      Related
      ENSP00000373250.4, ENST00000383744.8
      Conserved Domains (2) summary
      smart00431
      Location:38 → 150
      SCAN; leucine rich region
      pfam01352
      Location:216 → 257
      KRAB; KRAB box

    4. NM_001323295.2 → NP_001310224.1  zinc finger protein 197 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC099669, BQ002665
      Conserved Domains (6) summary
      smart00349
      Location:14 → 54
      KRAB; krueppel associated box
      COG5048
      Location:221 → 650
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:197 → 217
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:615 → 637
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:685 → 710
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001323296.2 → NP_001310225.1  zinc finger protein 197 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC099669, BQ002665
      Conserved Domains (6) summary
      smart00349
      Location:4 → 44
      KRAB; krueppel associated box
      COG5048
      Location:211 → 640
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:187 → 207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:605 → 627
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:675 → 700
      zf-H2C2_2; Zinc-finger double domain

    6. NM_006991.5 → NP_008922.1  zinc finger protein 197 isoform 1

      See identical proteins and their annotated locations for NP_008922.1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC099669, AY261677, AY279353, BQ002665
      UniProtKB/Swiss-Prot
      B2RAH8, O14709, Q86VG0
      Related
      ENSP00000345809.4, ENST00000344387.9
      Conserved Domains (5) summary
      smart00431
      Location:38 → 150
      SCAN; leucine rich region
      COG5048
      Location:424 → 853
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:400 → 420
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:216 → 256
      KRAB; KRAB box
      pfam13465
      Location:384 → 409
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_136582.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC099669, AY279353, BC031209

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      44625036..44648471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646197.1 Reference GRCh38.p14 PATCHES

      Range
      150390..173825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      44640750..44664179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14709.1 GenPept UniProtKB/Swiss-Prot:O14709

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