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    HP1c Heterochromatin Protein 1c [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42696, updated on 10-May-2024

    Summary

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    Official Symbol
    HP1cprovided by FlyBase
    Official Full Name
    Heterochromatin Protein 1cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039019
    Locus tag
    Dmel_CG6990
    See related
    AllianceGenome:FB:FBgn0039019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6990; Dmel\CG6990; HP1; hp1c; Hp1c; HP1C
    Summary
    Enables chromatin binding activity; epigenetic reader; and methylated histone binding activity. Involved in regulation of transcription by RNA polymerase II and subtelomeric heterochromatin assembly. Located in euchromatin; nucleus; and polytene chromosome interband. Part of protein-containing complex. Is expressed in several structures, including adult head; embryonic brain; embryonic/larval nervous system; extended germ band embryo; and gonad. Orthologous to human CBX3 (chromobox 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See HP1c in Genome Data Viewer
    Location:
    94C4-94C4; 3-76 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22745620..22746605)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18571342..18572327)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Dicer-1 Neighboring gene uncharacterized protein Neighboring gene vreteno Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-specific protease 12/46 Neighboring gene rumi Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chromatin remodeling in the aging genome of Drosophila. Wood JG, et al. Aging Cell, 2010 Dec. PMID 20961390, Free PMC Article
    2. The Drosophila HP1 family is associated with active gene expression across chromatin contexts. Schoelz JM, et al. Genetics, 2021 Aug 26. PMID 34849911, Free PMC Article
    3. HP1c regulates development and gut homeostasis by suppressing Notch signaling through Su(H). Sun J, et al. EMBO Rep, 2021 Apr 7. PMID 33594776, Free PMC Article
    4. DNA microarray profiling of genes differentially regulated by three heterochromatin protein 1 (HP1) homologs in Drosophila. Lee DH, et al. Biochem Biophys Res Commun, 2013 May 17. PMID 23611785
    5. HP1c casts light on dark matter. Kwon SH, et al. Cell Cycle, 2011 Feb 15. PMID 21301224

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HP1 associates differently with RNA polymerase II; HP1a and HP1b, but not HP1c, inhibit transcriptional activity, suggesting that HP1c serves as a positive regulator in transcription.
      Title: Comparison of three heterochromatin protein 1 homologs in Drosophila.
    2. dDsk2 prevents dUbp8/Nonstop-dependent H2Bub1 deubiquitylation at promoters of dHP1c complex target genes and regulates RNA polymerase II pausing.
      Title: dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes.
    3. Data indicate significant similarity and uniqueness in the genes regulated by three HP1 homologs HP1a, HP1b, and HP1c.
      Title: DNA microarray profiling of genes differentially regulated by three heterochromatin protein 1 (HP1) homologs in Drosophila.
    4. interaction between HP1c and Woc constitutes a transcriptional feedback loop that operates to balance the concentration of HP1c within the cell
      Title: Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc.
    5. HP1c, WOC, and ROW regulate a common gene expression program that, in part, is executed in the context of the nervous system.
      Title: Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone reader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pericentric heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterochromatin protein 1c
    Names
    CG6990-PA
    HP1c-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22745620..22746605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142836.3 → NP_651093.1  heterochromatin protein 1c [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651093.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCU6
      Related
      FBpp0083702
      Conserved Domains (2) summary
      pfam00385
      Location:9 → 58
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      pfam01393
      Location:89 → 134
      Chromo_shadow; Chromo shadow domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCU6 Q9VCU6

    Gene LinkOut

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