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    rplV 50S ribosomal subunit protein L22 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947813, updated on 2-May-2024

    Summary

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    Gene symbol
    rplV
    Gene description
    50S ribosomal subunit protein L22
    Primary source
    ASAP:ABE-0010850
    Locus tag
    b3315
    See related
    ECOCYC:EG10882
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3302; eryB
    Summary
    The L22 protein is a component of the 50S subunit of the ribosome; it can interact with nascent translation products in the exit tunnel and provides one of the earliest contacts with a nascent peptide chain past the peptidyl transferase center . [More information is available at EcoCyc: EG10882].
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    Genomic context

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    Sequence:
    NC_000913.3 (3449901..3450233, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal subunit protein L29 Neighboring gene 50S ribosomal subunit protein L16 Neighboring gene 30S ribosomal subunit protein S3 Neighboring gene 30S ribosomal subunit protein S19 Neighboring gene 50S ribosomal subunit protein L2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22. Gabashvili IS, et al. Mol Cell, 2001 Jul. PMID 11511371
    2. Erythromycin inhibits the assembly of the large ribosomal subunit in growing Escherichia coli cells. Chittum HS, et al. Curr Microbiol, 1995 May. PMID 7766155
    3. A temperature-sensitive mutant of Escherichia coli with an alteration in ribosomal protein L22. Burnette-Vick B, et al. Genetica, 1994. PMID 7729693
    4. Amino acid sequence of protein L22 from the large subunit of the Escherichia coli ribosome. Wittmann-Liebold B, et al. FEBS Lett, 1980 Nov 17. PMID 7007072
    5. Protein synthesis defects in temperature-sensitive mutants of Escherichia coli with altered ribosomal proteins. Champney WS. Biochim Biophys Acta, 1980 Oct 17. PMID 6159923

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The extended loops of ribosomal proteins L4 and L22 of Escherichia coli contribute to ribosome assembly and protein translation.
      Title: The extended loops of ribosomal proteins uL4 and uL22 of Escherichia coli contribute to ribosome assembly and protein translation.
    2. The effects of classical erythromycin resistance mutations in ribosomal proteins L4 and L22 of the large ribosomal subunit on the kinetics of erythromycin binding, were characterized.
      Title: Erythromycin resistance by L4/L22 mutations and resistance masking by drug efflux pump deficiency.
    3. Our results highlight the important role of L4 and L22 in ribosome function and assembly, and indicate that a variety of changes in these proteins can mediate macrolide resistance.
      Title: Novel mutations in ribosomal proteins L4 and L22 that confer erythromycin resistance in Escherichia coli.
    4. N-terminus verified by Edman degradation on complete protein
      Title: Amino acid sequence of protein L22 from the large subunit of the Escherichia coli ribosome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables large ribosomal subunit rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within assembly of large subunit precursor of preribosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cytosolic ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of large ribosomal subunit IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    50S ribosomal subunit protein L22

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3449901..3450233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417774.1 50S ribosomal subunit protein L22 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417774.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T3UP55
      Conserved Domains (1) summary
      PRK00565
      Location:1 → 110
      rplV; 50S ribosomal protein L22; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    7BL5_S.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials