tpx lipid hydroperoxide peroxidase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: tpx
Gene description: lipid hydroperoxide peroxidase
Primary source: ASAP:ABE-0004442
Locus tag: b1324
See related: ECOCYC:G6660
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1320; yzzJ
Summary: Binds TrxA (Kumar, 2004). although initially reported to be a periplasmic enzyme, the formation of a mixed-disulfide complex with TrxA indicates a cytoplasmic localization (Tao, 2008). [More information is available at EcoGene: EG12672]. Tpx is a |FRAME: [More information is available at EcoCyc: G6660].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Structural alignments revealed that Tpx is conserved
Title: The structure of an orthorhombic crystal form of a 'forced reduced' thiol peroxidase reveals lattice formation aided by the presence of the affinity tag.
Results describe in detail the structural changes associated with catalysis in the thiol peroxidase subfamily.
Title: Structural changes common to catalysis in the Tpx peroxiredoxin subfamily.
N-terminus verified by Edman degradation on mature peptide
Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables hydroperoxide reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables thioredoxin peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables thioredoxin peroxidase activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin-dependent peroxiredoxin activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in periplasmic space	IEA Inferred from Electronic Annotation more info

NP_415840.1

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The following sections contain reference sequences that belong to a specific genome build. Explain