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    FRE4 ferric-chelate reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855797, updated on 17-May-2024

    Summary

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    Gene symbol
    FRE4
    Gene description
    ferric-chelate reductase
    Primary source
    FungiDB:YNR060W
    Locus tag
    YNR060W
    See related
    SGD:S000005343; AllianceGenome:SGD:S000005343; VEuPathDB:YNR060W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ferric-chelate reductase activity. Involved in siderophore transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FRE4 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (739951..742110)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene adenosylmethionine-8-amino-7-oxononanoate transaminase Neighboring gene putative alpha-1,3-mannosyltransferase Neighboring gene uncharacterized protein Neighboring gene Pul3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insufficiency of copper ion homeostasis causes freeze-thaw injury of yeast cells as revealed by indirect gene expression analysis. Takahashi S, et al. Appl Environ Microbiol, 2009 Nov. PMID 19749072, Free PMC Article
    2. Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae. Martins LJ, et al. J Biol Chem, 1998 Sep 11. PMID 9726978
    3. Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits. Herst PM, et al. FEMS Yeast Res, 2008 Sep. PMID 18657191
    4. The role of the FRE family of plasma membrane reductases in the uptake of siderophore-iron in Saccharomyces cerevisiae. Yun CW, et al. J Biol Chem, 2001 Mar 30. PMID 11120744
    5. Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes. Georgatsou E, et al. Yeast, 1999 May. PMID 10341420

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ferric-chelate reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferric-chelate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric-chelate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferric-chelate reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ferric-chelate reductase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ferric-chelate reductase
    NP_014458.1
    • Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      739951..742110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183237.1 → NP_014458.1  TPA: ferric-chelate reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014458.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1N5, P53746
      UniProtKB/TrEMBL
      A0A8H4BW11, B3LPI3, C7GIY5, C8ZFT9
      Conserved Domains (3) summary
      cd06186
      Location:428 → 596
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam08030
      Location:530 → 699
      NAD_binding_6; Ferric reductase NAD binding domain
      pfam01794
      Location:276 → 389
      Ferric_reduct; Ferric reductase like transmembrane component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53746.1

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