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    ATO2 putative ammonium permease ATO2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855736, updated on 17-May-2024

    Summary

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    Gene symbol
    ATO2
    Gene description
    putative ammonium permease ATO2
    Primary source
    FungiDB:YNR002C
    Locus tag
    YNR002C
    See related
    SGD:S000005285; AllianceGenome:SGD:S000005285; VEuPathDB:YNR002C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUN34
    Summary
    Enables ammonium transmembrane transporter activity. Involved in ammonium transmembrane transport and nitrogen utilization. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ATO2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (633008..633856, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA-Pro Neighboring gene tRNA-Asn Neighboring gene DNA-directed RNA polymerase III subunit C34 Neighboring gene Swm2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization, localization and functional analysis of Gpr1p, a protein affecting sensitivity to acetic acid in the yeast Yarrowia lipolytica. Augstein A, et al. Microbiology (Reading), 2003 Mar. PMID 12634328
    2. Evolutionary engineering reveals amino acid substitutions in Ato2 and Ato3 that allow improved growth of Saccharomyces cerevisiae on lactic acid. Baldi N, et al. FEMS Yeast Res, 2021 Jun 8. PMID 34042971
    3. Mutations at different sites in members of the Gpr1/Fun34/YaaH protein family cause hypersensitivity to acetic acid in Saccharomyces cerevisiae as well as in Yarrowia lipolytica. Gentsch M, et al. FEMS Yeast Res, 2007 May. PMID 17233767
    4. Physiological regulation of yeast cell death in multicellular colonies is triggered by ammonia. Váchová L, et al. J Cell Biol, 2005 Jun 6. PMID 15939758, Free PMC Article
    5. Association of putative ammonium exporters Ato with detergent-resistant compartments of plasma membrane during yeast colony development: pH affects Ato1p localisation in patches. Ricicová M, et al. Biochim Biophys Acta, 2007 May. PMID 17395151

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evolutionary engineering reveals amino acid substitutions in Ato2 and Ato3 that allow improved growth of Saccharomyces cerevisiae on lactic acid.
      Title: Evolutionary engineering reveals amino acid substitutions in Ato2 and Ato3 that allow improved growth of Saccharomyces cerevisiae on lactic acid.
    2. there is an interaction between molecules of the same Ato protein, namely Ato1p-Ato1p and Ato3p-Ato3p, but not Ato2p-Ato2p
      Title: Ato protein interactions in yeast plasma membrane revealed by fluorescence lifetime imaging (FLIM).
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acetate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ammonium transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ammonium transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ammonium transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative ammonium permease ATO2
    NP_014399.3
    • Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      633008..633856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183179.3 → NP_014399.3  TPA: putative ammonium permease ATO2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014399.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1H8, P32907
      UniProtKB/TrEMBL
      A0A6A5Q446, A6ZS77, B3LPN7, B5VR35, C7GLQ2, C8ZFM8, G2WL60, N1P4N7
      Conserved Domains (1) summary
      pfam01184
      Location:70 → 275
      Grp1_Fun34_YaaH; GPR1/FUN34/yaaH family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32907.1

    Gene LinkOut

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