BDP1 transcription factor TFIIIB subunit BDP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: BDP1
Gene description: transcription factor TFIIIB subunit BDP1
Primary source: FungiDB:YNL039W
Locus tag: YNL039W
See related: SGD:S000004984; AllianceGenome:SGD:S000004984; VEuPathDB:YNL039W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TFC5; TFC7
Summary: Enables TFIIIC-class transcription factor complex binding activity. Involved in DNA-templated transcription open complex formation; RNA polymerase III preinitiation complex assembly; and positive regulation of transposon integration. Part of transcription factor TFIIIB complex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 112. Orthologous to human BDP1 (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BDP1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (555048..556832)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These analyses identified an essential region of Bdp1 that is positioned within the active site cleft of Pol III and necessary for transcription initiation.
Title: A Region of Bdp1 Necessary for Transcription Initiation That Is Located within the RNA Polymerase III Active Site Cleft.
A structural model of the interaction interface between Bdp1 (RNA poplymerase III essential subunit) and Brf1 (TFIIIB B-related factor) shows the main Bdp1 anchorage site provided by a small set of residues belonging to a Brf1 segment of residues 470-495.
Title: Structural characterization of the interaction between TFIIIB components Bdp1 and Brf1.
Entry of Brf1 and Bdp1 into the transcription complex imposes a strict sequence preference for the downstream half of the TATA box that matches the TATA box of the pol III-transcribed U6 small nuclear RNA gene.
Title: The Saccharomyces cerevisiae RNA polymerase III recruitment factor subunits Brf1 and Bdp1 impose a strict sequence preference for the downstream half of the TATA box.
Bdp1p is required for periodic integration of the Ty1 retrotransposon and targeting of Isw2p to tDNAs.
Title: TFIIIB subunit Bdp1p is required for periodic integration of the Ty1 retrotransposon and targeting of Isw2p to S. cerevisiae tDNAs.
analysis of the interaction site of the Brf1 and Bdp1 subunits of Saccharomyces cerevisiae TFIIIB
Title: Mapping the principal interaction site of the Brf1 and Bdp1 subunits of Saccharomyces cerevisiae TFIIIB.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA polymerase III general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
enables TFIIIC-class transcription factor complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables TFIIIC-class transcription factor complex binding	IDA Inferred from Direct Assay more info	PubMed
enables TFIIIC-class transcription factor complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription open complex formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in RNA polymerase III preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase III preinitiation complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA polymerase III preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase III	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIIB complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIIB complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIIB complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor TFIIIB subunit BDP1

NP_014359.3

Essential subunit of RNA polymerase III transcription factor (TFIIIB); TFIIIB is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

555048..556832

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182878.3 → NP_014359.3 TPA: transcription factor TFIIIB subunit BDP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014359.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1E0, P46678

UniProtKB/TrEMBL

A0A6A5Q5A9, B3LNQ1, B5VQZ8, C7GLW1, C8ZGJ0, G2WM64, N1NXL8

Conserved Domains (1) summary

COG5118
Location:34 → 566

BDP1; Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]