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    YHM2 Yhm2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855282, updated on 17-May-2024

    Summary

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    Gene symbol
    YHM2
    Gene description
    Yhm2p
    Primary source
    FungiDB:YMR241W
    Locus tag
    YMR241W
    See related
    SGD:S000004854; AllianceGenome:SGD:S000004854; VEuPathDB:YMR241W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA binding activity and tricarboxylate secondary active transmembrane transporter activity. Involved in alpha-ketoglutarate transport; mitochondrial citrate transmembrane transport; and mitochondrial genome maintenance. Located in mitochondrial nucleoid. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YHM2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (751961..752905)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribonuclease III Neighboring gene U2 snRNP complex subunit CUS1 Neighboring gene ribosomal 60S subunit protein L20A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel DNA-binding protein bound to the mitochondrial inner membrane restores the null mutation of mitochondrial histone Abf2p in Saccharomyces cerevisiae. Cho JH, et al. Mol Cell Biol, 1998 Oct. PMID 9742088, Free PMC Article
    2. Three mitochondrial transporters of Saccharomyces cerevisiae are essential for ammonium fixation and lysine biosynthesis in synthetic minimal medium. Scarcia P, et al. Mol Genet Metab, 2017 Nov. PMID 28784321
    3. Identification and functional characterization of a novel mitochondrial carrier for citrate and oxoglutarate in Saccharomyces cerevisiae. Castegna A, et al. J Biol Chem, 2010 Jun 4. PMID 20371607, Free PMC Article
    4. Bacterial overexpression of putative yeast mitochondrial transport proteins. Mayor JA, et al. J Bioenerg Biomembr, 1997 Dec. PMID 9559855
    5. Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p. Chalermwat C, et al. FEMS Yeast Res, 2019 Dec 1. PMID 31711143, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yhm2p is a mitochondrial transporter for citrate and oxoglutarate
      Title: Identification and functional characterization of a novel mitochondrial carrier for citrate and oxoglutarate in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tricarboxylate secondary active transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tricarboxylate secondary active transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in alpha-ketoglutarate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in alpha-ketoglutarate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial citrate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial citrate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tricarboxylic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Yhm2p
    NP_013968.1
    • Citrate and oxoglutarate carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      751961..752905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182748.1 → NP_013968.1  TPA: Yhm2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013968.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W067, Q04013
      UniProtKB/TrEMBL
      A0A6A5PVH7, A6ZMV4, B3LMC9, B5VQ10, C7GRB0, C8ZFA6, G2WKU9, N1P0L2
      Conserved Domains (1) summary
      pfam00153
      Location:211 → 305
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04013.1

    Gene LinkOut

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