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    CKA1 casein kinase 2 catalytic subunit CKA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854776, updated on 17-May-2024

    Summary

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    Gene symbol
    CKA1
    Gene description
    casein kinase 2 catalytic subunit CKA1
    Primary source
    FungiDB:YIL035C
    Locus tag
    YIL035C
    See related
    SGD:S000001297; AllianceGenome:SGD:S000001297; VEuPathDB:YIL035C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including donor selection; protein phosphorylation; and regulation of transcription, DNA-templated. Part of UTP-C complex and protein kinase CK2 complex. Orthologous to several human genes including CSNK2A1 (casein kinase 2 alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CKA1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (287790..288908, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene pheromone-regulated protein PRM2 Neighboring gene Cst6p Neighboring gene F-actin-capping protein subunit beta Neighboring gene cAMP-dependent protein kinase regulatory subunit BCY1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation, sequencing, and disruption of the CKA1 gene encoding the alpha subunit of yeast casein kinase II. Chen-Wu JL, et al. Mol Cell Biol, 1988 Nov. PMID 3062376, Free PMC Article
    2. Catalytic activity of mutants of yeast protein kinase CK2alpha. Sajnaga E, et al. Acta Biochim Pol, 2008. PMID 19015772
    3. Minimal CK2 activity required for yeast growth. Hermosilla GH, et al. Mol Cell Biochem, 2005 Jun. PMID 16335527
    4. Different properties of four molecular forms of protein kinase CK2 from Saccharomyces cerevisiae. Domańska K, et al. Acta Biochim Pol, 2005. PMID 16265593
    5. Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiae. Cheung WL, et al. Curr Biol, 2005 Apr 12. PMID 15823538

    See all (163) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae has been described.
      Title: Role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae.
    2. The authors provide strong evidence that Cka1p regulates Ycf1p function via phosphorylation of Ser251.
      Title: Suppression of Ycf1p function by Cka1p-dependent phosphorylation is attenuated in response to salt stress.
    3. protein kinase CK2 phosphorylates Ser(361) on Sgt1, and this phosphorylation inhibits Sgt1 dimerization
      Title: Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361.
    4. Studies in yeast and in human cells demonstrate that the different forms of CK2 interact with a large number of cellular proteins.
      Title: The emerging CK2 interactome: insights into the regulation and functions of CK2.
    5. Cka1p may regulate Ycf1p function through phosphorylation of Ser-251 either directly or indirectly.
      Title: Negative regulation of the yeast ABC transporter Ycf1p by phosphorylation within its N-terminal extension.
    6. Yeast transcription elongation factor Elf1 has been identified as a new substrate for protein kinase CK2 and coimmunoprecipitation shows that Elf1 interacts with catalytic (alpha and alpha') as well as regulatory (beta and beta') subunits of CK2.
      Title: Yeast elf1 factor is phosphorylated and interacts with protein kinase CK2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in donor selection IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of UTP-C complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase CK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase CK2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    casein kinase 2 catalytic subunit CKA1
    NP_012229.1
    • Alpha catalytic subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      287790..288908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179385.1 → NP_012229.1  TPA: casein kinase 2 catalytic subunit CKA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012229.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVP7, P15790
      UniProtKB/TrEMBL
      A0A6A5Q2X6, A6ZVN4, B3LTP1, B5VKR1, C7GVW3, C8ZAL1, G2WGB1, N1P271
      Conserved Domains (1) summary
      cd14132
      Location:21 → 363
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15790.1

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