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    RPL17B ribosomal 60S subunit protein L17B [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853262, updated on 17-May-2024

    Summary

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    Gene symbol
    RPL17B
    Gene description
    ribosomal 60S subunit protein L17B
    Primary source
    FungiDB:YJL177W
    Locus tag
    YJL177W
    See related
    SGD:S000003713; AllianceGenome:SGD:S000003713; VEuPathDB:YJL177W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of ribosome. Involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and cytoplasmic translation. Part of cytosolic large ribosomal subunit and preribosome, large subunit precursor. Orthologous to several human genes including RPL17-C18orf32 (RPL17-C18orf32 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPL17B in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    2
    Sequence:
    Chromosome: X; NC_001142.9 (90786..91657)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene prefolding complex chaperone subunit Neighboring gene Atg27p Neighboring gene Swi3p Neighboring gene Kre9p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A single N(1)-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes. Sharma S, et al. Sci Rep, 2018 Aug 9. PMID 30093689, Free PMC Article
    2. A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates. Neal S, et al. J Biol Chem, 2017 Feb 24. PMID 28077573, Free PMC Article
    3. Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae. Egbe NE, et al. Microb Cell, 2017 Sep 4. PMID 28913344, Free PMC Article
    4. Tandem affinity purification revealed the hypusine-dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex. Jao DL, et al. J Cell Biochem, 2006 Feb 15. PMID 16215987
    5. Ribosome assembly factors Pwp1 and Nop12 are important for folding of 5.8S rRNA during ribosome biogenesis in Saccharomyces cerevisiae. Talkish J, et al. Mol Cell Biol, 2014 May. PMID 24636992, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L17B
    NP_012358.1
    • Ribosomal 60S subunit protein L17B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      90786..91657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181610.1 → NP_012358.1  TPA: ribosomal 60S subunit protein L17B [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012358.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW12, P46990
      UniProtKB/TrEMBL
      A6ZQF7, B3LPU8, C7GS03, C8ZB42, G2WGJ8, N1P3T4
      Conserved Domains (1) summary
      PTZ00178
      Location:1 → 184
      PTZ00178; 60S ribosomal protein L17; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46990.2

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