CLD1 carboxylic ester hydrolase [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: CLD1
Gene description: carboxylic ester hydrolase
Primary source: FungiDB:YGR110W
Locus tag: YGR110W
See related: SGD:S000003342; AllianceGenome:SGD:S000003342; VEuPathDB:YGR110W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phospholipase A2 activity. Involved in cardiolipin acyl-chain remodeling. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1 and neutral lipid storage disease. Orthologous to human ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B) and ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Data suggest that CLD1 expression is required to mitigate oxidative stress through mitigating the effect of cardiolipin peroxidation.
Title: Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation.
transcriptional regulation of Cld1-mediated deacylation of CL influences energy metabolism by modulating the relative contribution of glycolysis and respiration.
Title: Deletion of the cardiolipin-specific phospholipase Cld1 rescues growth and life span defects in the tafazzin mutant: implications for Barth syndrome.
Data indicate that monolysocardiolipin generated by Cld1p must be transported to intermembrane space (IMS)-facing membrane leaflets to gain access to tafazzin (TAZ1) for cardiolipin (CL) remodeling.
Title: Deacylation on the matrix side of the mitochondrial inner membrane regulates cardiolipin remodeling.
YGR110W (CLD1) is a cardiolipin-specific phospholipase
Title: Identification of a cardiolipin-specific phospholipase encoded by the gene CLD1 (YGR110W) in yeast.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiolipin acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin acyl-chain remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiolipin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiolipin metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_011625.3

Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58