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    ATE1 arginyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852867, updated on 17-May-2024

    Summary

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    Gene symbol
    ATE1
    Gene description
    arginyltransferase
    Primary source
    FungiDB:YGL017W
    Locus tag
    YGL017W
    See related
    SGD:S000002985; AllianceGenome:SGD:S000002985; VEuPathDB:YGL017W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables arginyltransferase activity. Involved in protein arginylation. Located in cytoplasm. Orthologous to human ATE1 (arginyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ATE1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (459854..461365)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene casein kinase 2 regulatory subunit CKB1 Neighboring gene J-type chaperone JAC1 Neighboring gene Kap122p Neighboring gene Bil2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assaying ATE1 Activity in Yeast by β-Gal Degradation. Kashina AS. Methods Mol Biol, 2015. PMID 26285881
    2. Enzymatic generation of peptides flanked by basic amino acids to obtain MS/MS spectra with 2× sequence coverage. Ebhardt HA, et al. Rapid Commun Mass Spectrom, 2014 Dec 30. PMID 25380496, Free PMC Article
    3. A mutant of Saccharomyces cerevisiae defective in arginyl-tRNA-protein transferase. Savage M, et al. Curr Genet, 1983 Jul. PMID 24173338
    4. Inactivation of arginyl-tRNA protein transferase by a bifunctional arsenoxide: identification of residues proximal to the arsenoxide site. Li J, et al. Biochemistry, 1995 Jan 10. PMID 7819189
    5. Cloning and functional analysis of the arginyl-tRNA-protein transferase gene ATE1 of Saccharomyces cerevisiae. Balzi E, et al. J Biol Chem, 1990 May 5. PMID 2185248

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role is identified for Ate1 in modulating the level of topoisomerase II through the cell cycle.
      Title: The identification and characterisation of a functional interaction between arginyl-tRNA-protein transferase and topoisomerase II.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginyl-tRNA--protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginyl-tRNA--protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arginyl-tRNA--protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginyl-tRNA--protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein arginylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein arginylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein arginylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arginyltransferase
    NP_011498.1
    • Arginyl-tRNA-protein transferase; catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway; may have a role in regulating stress response

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      459854..461365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180882.1 → NP_011498.1  TPA: arginyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011498.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUC0, P16639
      UniProtKB/TrEMBL
      A0A8H4C2T6, G2WE76, N1P3Q1
      Conserved Domains (1) summary
      COG2935
      Location:23 → 346
      Ate1; Arginyl-tRNA--protein-N-Asp/Glu arginylyltransferase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16639.2

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