HEH2 Heh2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: HEH2
Gene description: Heh2p
Primary source: FungiDB:YDR458C
Locus tag: YDR458C
See related: SGD:S000002866; AllianceGenome:SGD:S000002866; VEuPathDB:YDR458C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable chromatin binding activity. Located in nuclear envelope. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome. Orthologous to human LEMD3 (LEM domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HEH2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1380055..1382046, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state.
Title: Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state.
Flexible and Extended Linker Domains Support Efficient Targeting of Heh2 to the Inner Nuclear Membrane.
Title: Flexible and Extended Linker Domains Support Efficient Targeting of Heh2 to the Inner Nuclear Membrane.
The conserved features of the NLSs of ScHeh1, ScHeh2, and RnPom121 and the effective sorting of Heh2-derived reporters in human cells suggest that active import is conserved but confined to a small subset of INM proteins.
Title: Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins.
Heh2 and Src1/Heh1 contain bipartite import sequences that associate intimately with the minor nuclear localization sequence-binding pocket of yeast importin alpha.
Title: Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.
study found that at least a 120-residue-long intrinsically disordered linker was required for the import of membrane proteins carrying a nuclear localization signal for the transport factor karyopherin-alpha
Title: Long unfolded linkers facilitate membrane protein import through the nuclear pore complex.
In the absence of the Kap60-44, Kap60-30 and Kap60-10 isoforms, Heh2 localized to cytoplasmic membranes, whereas its wild-type localization at the nuclear periphery was restored when the Kap60-44 isoform was reintroduced.
Title: Truncated isoforms of Kap60 facilitate trafficking of Heh2 to the nuclear envelope.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in nuclear membrane organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	HDA more info	PubMed
is_active_in nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in organelle envelope	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Heh2p

NP_010746.1

Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle; HEH2 has a paralog, SRC1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1380055..1382046 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180766.1 → NP_010746.1 TPA: Heh2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010746.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT82, Q03281

UniProtKB/TrEMBL

A0A8H8UNZ1, B3LFK7, B5VGZ0, C7GKP9, C8Z616, N1PAK5

Conserved Domains (2) summary

cd12935
Location:8 → 42

LEM_like; LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins

pfam09402
Location:330 → 661

MSC; Man1-Src1p-C-terminal domain