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    RTR2 putative protein-serine/threonine phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851638, updated on 17-May-2024

    Summary

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    Gene symbol
    RTR2
    Gene description
    putative protein-serine/threonine phosphatase
    Primary source
    FungiDB:YDR066C
    Locus tag
    YDR066C
    See related
    SGD:S000002473; AllianceGenome:SGD:S000002473; VEuPathDB:YDR066C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in dephosphorylation of RNA polymerase II C-terminal domain. Located in cytoplasm and nucleus. Orthologous to human RPAP2 (RNA polymerase II associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RTR2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (581908..582498, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S13 Neighboring gene Rrg1p Neighboring gene protein-tyrosine-phosphatase Neighboring gene Dos2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins. Gibney PA, et al. Eukaryot Cell, 2008 Jun. PMID 18408053, Free PMC Article
    2. Different pathways for the nuclear import of yeast RNA polymerase II. Gómez-Navarro N, et al. Biochim Biophys Acta, 2015 Nov. PMID 26455955
    3. New insight into the role of the Cdc34 ubiquitin-conjugating enzyme in cell cycle regulation via Ace2 and Sic1. Cocklin R, et al. Genetics, 2011 Mar. PMID 21196523, Free PMC Article
    4. Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability. Strome ED, et al. Genetics, 2008 Mar. PMID 18245329, Free PMC Article
    5. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative protein-serine/threonine phosphatase
    NP_010351.1
    • hypothetical protein; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      581908..582498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180374.1 → NP_010351.1  TPA: putative protein-serine/threonine phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010351.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS52, Q12378
      UniProtKB/TrEMBL
      A0A8H8UMY2, N1P835
      Conserved Domains (1) summary
      pfam04181
      Location:55 → 115
      RPAP2_Rtr1; Rtr1/RPAP2 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12378.1

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