UTP21 rRNA-processing protein UTP21 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Gene symbol: UTP21
Gene description: rRNA-processing protein UTP21
Primary source: FungiDB:YLR409C
Locus tag: YLR409C
See related: SGD:S000004401; AllianceGenome:SGD:S000004401; VEuPathDB:YLR409C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in rRNA processing. Located in nucleolus. Part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Human ortholog(s) of this gene implicated in glaucoma and primary open angle glaucoma. Orthologous to human WDR36 (WD repeat domain 36). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See UTP21 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (934414..937233, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Residues 100-190 of Utp18 bind to the tandem WD domain of Utp21.
Title: Structure of Utp21 tandem WD domain provides insight into the organization of the UTPB complex involved in ribosome synthesis.
The interaction between the half-a-tetratricopeptide repeat (HAT) domain of Utp6 and a specific peptide in Utp21, is investigated.
Title: A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 90S preribosome	HDA more info	PubMed
part_of Pwp2p-containing subcomplex of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
part_of Pwp2p-containing subcomplex of 90S preribosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed
part_of small-subunit processome	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: rRNA-processing protein UTP21

NP_013513.3

Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma; Small Subunit processome is also known as SSU processome

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

934414..937233 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182297.3 → NP_013513.3 TPA: rRNA-processing protein UTP21 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013513.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZ43, Q06078

UniProtKB/TrEMBL

A0A8H4FA38, N1NYT4

Conserved Domains (4) summary

cd00200
Location:284 → 613

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:464 → 500

7WD40; WD40 repeat [structural motif]

pfam04192
Location:695 → 937

Utp21; Utp21 specific WD40 associated putative domain

cl29593
Location:81 → 377

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
5JPQ_I.1
6KE6_BE.1
6LQP_BE.1
6LQQ_BE.1
6LQR_BE.1
6LQS_BE.1
6LQT_BE.1
6LQU_BE.1
6LQV_BE.1
6ZQA_u.1
6ZQB_u.1
6ZQC_u.1
6ZQD_u.1
6ZQE_u.1
6ZQF_u.1
7AJT_u.1
7AJU_u.1
Q06078.1