GCD7 translation initiation factor eIF2B subunit beta [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: GCD7
Gene description: translation initiation factor eIF2B subunit beta
Primary source: FungiDB:YLR291C
Locus tag: YLR291C
See related: SGD:S000004282; AllianceGenome:SGD:S000004282; VEuPathDB:YLR291C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables enzyme regulator activity and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in regulation of translational initiation. Located in cytosol and mitochondrion. Part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GCD7 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (718317..719462, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings provide compelling evidence that beta/Gcd7 is crucial for binding of substrate by eIF2B in vivo, beyond its dispensable regulatory role in the inhibition of eIF2B by eIF
Title: The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo.
The eIF2/eIF5 complex represents a cytoplasmic reservoir for eIF2 that antagonizes eIF2B-promoted guanine nucleotide exchange, enabling coordinated regulation of translation initiation.
Title: An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation.
These data show that multiple contacts between eIF2gamma and eIF2Bepsilon mediate nucleotide exchange.
Title: Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables enzyme regulator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables enzyme regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to guanyl-nucleotide exchange factor activity	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables translation initiation factor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translational initiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translational initiation	IPI Inferred from Physical Interaction more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2B complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2B complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 2B complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of eukaryotic translation initiation factor 2B complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of eukaryotic translation initiation factor 2B complex	IPI Inferred from Physical Interaction more info	PubMed
part_of guanyl-nucleotide exchange factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of guanyl-nucleotide exchange factor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: translation initiation factor eIF2B subunit beta

NP_013394.1

Beta subunit of translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as negative regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog can complement yeast mutant, allows growth down-regulation of yeast gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

718317..719462 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182179.1 → NP_013394.1 TPA: translation initiation factor eIF2B subunit beta [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013394.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYT7, P32502

UniProtKB/TrEMBL

A0A8H4FA05, A7A1H4, B3RHH1, B5VNJ7, C7GVU6, C8ZDQ5, G2WJB5, N1NZZ0

Conserved Domains (1) summary

COG1184
Location:17 → 370

GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]