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    FRE6 putative ferric-chelate reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850675, updated on 17-May-2024

    Summary

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    Gene symbol
    FRE6
    Gene description
    putative ferric-chelate reductase
    Primary source
    FungiDB:YLL051C
    Locus tag
    YLL051C
    See related
    SGD:S000003974; AllianceGenome:SGD:S000003974; VEuPathDB:YLL051C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ferric-chelate reductase activity. Involved in copper ion import and intracellular sequestering of iron ion. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FRE6 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (37333..39471, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Aqy2p Neighboring gene cofilin Neighboring gene Ldb18p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The metalloreductase Fre6p in Fe-efflux from the yeast vacuole. Singh A, et al. J Biol Chem, 2007 Sep 28. PMID 17681937
    2. Identification of a vacuole-associated metalloreductase and its role in Ctr2-mediated intracellular copper mobilization. Rees EM, et al. J Biol Chem, 2007 Jul 27. PMID 17553781
    3. Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae. Martins LJ, et al. J Biol Chem, 1998 Sep 11. PMID 9726978
    4. Exploring metal ion metabolisms to improve xylose fermentation in Saccharomyces cerevisiae. Palermo GCL, et al. Microb Biotechnol, 2021 Sep. PMID 34313008, Free PMC Article
    5. Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes. Wuttke D, et al. PLoS Genet, 2012. PMID 22912585, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ferric-chelate reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferric-chelate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric-chelate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferric-chelate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferric-chelate reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ferric-chelate reductase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in copper ion import IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transition metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative ferric-chelate reductase
    NP_013049.1
    • Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      37333..39471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181871.1 → NP_013049.1  TPA: putative ferric-chelate reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013049.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXV7, Q12473
      UniProtKB/TrEMBL
      A0A8H4BZ49, A7A0K9, B3LTC6, B5VMQ1, C7GNE4, N1P6D1
      Conserved Domains (3) summary
      pfam08022
      Location:438 → 544
      FAD_binding_8; FAD-binding domain
      pfam08030
      Location:565 → 692
      NAD_binding_6; Ferric reductase NAD binding domain
      pfam01794
      Location:290 → 402
      Ferric_reduct; Ferric reductase like transmembrane component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12473.1

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