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    CAK1 cyclin-dependent protein kinase-activating kinase CAK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850515, updated on 17-May-2024

    Summary

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    Gene symbol
    CAK1
    Gene description
    cyclin-dependent protein kinase-activating kinase CAK1
    Primary source
    FungiDB:YFL029C
    Locus tag
    YFL029C
    See related
    SGD:S000001865; AllianceGenome:SGD:S000001865; VEuPathDB:YFL029C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CIV1
    Summary
    Enables cyclin-dependent protein kinase activating kinase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; negative regulation of transcription initiation from RNA polymerase II promoter; and protein phosphorylation. Located in cytoplasm. Used to study cystinosis; encephalitis; and intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CAK1 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (78055..79161, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene transcription factor HAC1 Neighboring gene alanine--glyoxylate transaminase Neighboring gene putative ATP-binding cassette family ATPase CAF16 Neighboring gene GTPase-activating protein GYP8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Potential roles for autophosphorylation, kinase activity, and abundance of a CDK-activating kinase (Ee;CDKF;1) during growth in leafy spurge. Chao WS, et al. Plant Mol Biol, 2007 Feb. PMID 17063377
    2. Kinetic analysis of the cyclin-dependent kinase-activating kinase (Cak1p) from budding yeast. Enke DA, et al. J Biol Chem, 2000 Oct 27. PMID 10934199
    3. The effects of changing the site of activating phosphorylation in CDK2 from threonine to serine. Kaldis P, et al. J Biol Chem, 2000 Oct 20. PMID 10931829
    4. The CDK-activating kinase (Cak1p) from budding yeast has an unusual ATP-binding pocket. Enke DA, et al. J Biol Chem, 1999 Jan 22. PMID 9890950
    5. Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities. Kaldis P, et al. Mol Biol Cell, 1998 Sep. PMID 9725911, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. unusual stability of this Cak1:Cdc37 association may partly reflect unique structural features of the fungal Cak1
      Title: Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1).
    2. While Cak1 is constitutively active and expressed, dividing cells tightly regulate Cak1 protein levels to ensure presence of adequate levels of Cdc28 CDK activity.
      Title: A phosphorylation-independent role for the yeast cyclin-dependent kinase activating kinase Cak1.
    3. Hyperpolarized growth of Saccharomyces cerevisiae cak1P212S and cla4 mutants weakens cell walls and renders cells dependent on chitin synthase 3.
      Title: Hyperpolarized growth of Saccharomyces cerevisiae cak1P212S and cla4 mutants weakens cell walls and renders cells dependent on chitin synthase 3.
    4. Ctk1 phosphorylation on Thr-338 is carried out by Cak1 and is required for normal gene transcription during the transition into stationary phase
      Title: Phosphorylation by Cak1 regulates the C-terminal domain kinase Ctk1 in Saccharomyces cerevisiae.
    5. the interactions linking Cak1 with the PAF1 complex and with Ssu72 are not direct but mediated via Ctk1 and Bur1
      Title: Kinase Cak1 functionally interacts with the PAF1 complex and phosphatase Ssu72 via kinases Ctk1 and Bur1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein kinase activating kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein kinase activating kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription initiation by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent protein kinase-activating kinase CAK1
    NP_116624.1
    • Cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases; required for premeiotic DNA synthesis, expression of early and middle sporulation specific genes and direct phosphorylation of the Smk1p MAPK to regulate spore morphogenesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      78055..79161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179937.1 → NP_116624.1  TPA: cyclin-dependent protein kinase-activating kinase CAK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116624.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTK1, P43568
      UniProtKB/TrEMBL
      A0A8H8UL53, A7A210, C7GY82, G2WDB2, N1P4W8
      Conserved Domains (1) summary
      cl21453
      Location:13 → 234
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43568.1

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