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    IQCF6 IQ motif containing F6 [ Homo sapiens (human) ]

    Gene ID: 440956, updated on 8-Mar-2024

    Summary

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    Official Symbol
    IQCF6provided by HGNC
    Official Full Name
    IQ motif containing F6provided by HGNC
    Primary source
    HGNC:HGNC:35158
    See related
    Ensembl:ENSG00000214686 AllianceGenome:HGNC:35158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable calmodulin binding activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 2.2) See more
    Orthologs
    mouse all
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    Genomic context

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    See IQCF6 in Genome Data Viewer
    Location:
    3p21.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (51778563..51779237, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (51811579..51812253, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51812579..51813253, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene testis expressed 264, ER-phagy receptor Neighboring gene RNA, 5S ribosomal pseudogene 132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51737956-51738824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51750466-51751323 Neighboring gene glutamate metabotropic receptor 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:51776905-51777405 Neighboring gene uncharacterized LOC105377087 Neighboring gene NANOG hESC enhancer GRCh37_chr3:51835876-51836627 Neighboring gene IQ motif containing F4, pseudogene Neighboring gene IQ motif containing F3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    IQ domain-containing protein F6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143833.4 → NP_001137305.2  IQ domain-containing protein F6 isoform 3

      See identical proteins and their annotated locations for NP_001137305.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC099050
      UniProtKB/Swiss-Prot
      A8MYZ5
      Related
      ENSP00000381760.3, ENST00000398780.5

    2. NM_001368368.1 → NP_001355297.1  IQ domain-containing protein F6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC099050
      Consensus CDS
      CCDS93281.1
      UniProtKB/TrEMBL
      A0A2R8Y4M9
      Related
      ENSP00000494187.1, ENST00000647442.1

    3. NM_001368369.1 → NP_001355298.1  IQ domain-containing protein F6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC099050
      Consensus CDS
      CCDS93280.1
      UniProtKB/TrEMBL
      A0A590UJ54
      Related
      ENSP00000499268.1, ENST00000667863.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      51778563..51779237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      51811579..51812253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MYZ5.3 GenPept UniProtKB/Swiss-Prot:A8MYZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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