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    HOXA@ homeobox A cluster [ Homo sapiens (human) ]

    Gene ID: 3197, updated on 29-Jan-2023

    Summary

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    Official Symbol
    HOXA@provided by HGNC
    Official Full Name
    homeobox A clusterprovided by HGNC
    Primary source
    HGNC:HGNC:5098
    Gene type
    other
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOX1@
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    7p15.2

    Bibliography

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    Related articles in PubMed

    1. Familial deletion of the HOXA gene cluster associated with Hand-Foot-Genital syndrome and phenotypic variability. Tas E, et al. Am J Med Genet A, 2017 Jan. PMID 27649277
    2. An early thymic precursor phenotype predicts outcome exclusively in HOXA-overexpressing adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study. Bond J, et al. Haematologica, 2016 Jun. PMID 26944475, Free PMC Article
    3. Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML. Kok CH, et al. Leukemia, 2010 Jun. PMID 20428200
    4. [Aberrant methylation at promoter region of HOX A gene cluster in leukemia cells]. Fang MH, et al. Zhonghua Xue Ye Xue Za Zhi, 2009 Jul. PMID 19954601
    5. Implication of long-distance regulation of the HOXA cluster in a patient with postaxial polydactyly. Lodder EM, et al. Chromosome Res, 2009. PMID 19672683, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Changes in Hox Gene Chromatin Organization during Odontogenic Lineage Specification.
      Title: Changes in Hox Gene Chromatin Organization during Odontogenic Lineage Specification.
    2. Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells.
      Title: Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells.
    3. this is the first familial 7p15.2 deletion. This family raises possibility for sexual dimorphism as a mechanism for phenotypic variability in patients with the HOXA gene cluster deletions.
      Title: Familial deletion of the HOXA gene cluster associated with Hand-Foot-Genital syndrome and phenotypic variability.
    4. HOTAIRM1 contributes to three-dimensional chromatin organization changes required for the temporal collinear activation of HOXA genes. Distinct HOTAIRM1 variants preferentially associate with either UTX/MLL or PRC2 complexes to modulate the levels of activating and silencing marks at the bivalent domain.
      Title: Reciprocal regulation of chromatin state and architecture by HOTAIRM1 contributes to temporal collinear HOXA gene activation.
    5. the underlying mechanism of HOXA deregulation dictates the clinico-biological phenotype, and that the negative prognosis of early thymic precursor acute lymphoblastic leukemia is exclusive to HOXA-positive patients, suggesting that early treatment intensification is currently suboptimal for therapeutic rescue of HOXA-positive chemoresistant adult early thymic precursor acute lymphoblastic leukemia.
      Title: An early thymic precursor phenotype predicts outcome exclusively in HOXA-overexpressing adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.
    6. The results indicate that the initial chromatin conformation affects subsequent RA-induced HOXA gene activation. Our study uncovers that a removable insulator spatiotemporally switches higher-order chromatin and multiple gene activities via cooperation of CTCF and key transcription factors.
      Title: DNA methylation-independent removable insulator controls chromatin remodeling at the HOXA locus via retinoic acid signaling.
    7. CTCF/cohesin coordinates HOXA cluster higher-order chromatin structure and expression during development
      Title: Exploring CTCF and cohesin related chromatin architecture at HOXA gene cluster in primary human fibroblasts.
    8. Functional characterization of this RNA suggests that the transcript stabilizes long-range interactions at the HOXA locus and promotes proper expression of HOXA genes
      Title: Boundary Associated Long Noncoding RNA Mediates Long-Range Chromosomal Interactions.
    9. Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.
      Title: Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.
    10. In all leukemia cell lines, aberrant methylation of CpGs was observed at promoter regions of 6 HOX A cluster genes, and some of these genes showed leukemia-type-specific hypermethylation.
      Title: [Aberrant methylation at promoter region of HOX A gene cluster in leukemia cells].
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    General gene information

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    Other Names

    • homeo box A cluster

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