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    IL17RB interleukin 17 receptor B [ Homo sapiens (human) ]

    Gene ID: 55540, updated on 5-Mar-2024

    Summary

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    Official Symbol
    IL17RBprovided by HGNC
    Official Full Name
    interleukin 17 receptor Bprovided by HGNC
    Primary source
    HGNC:HGNC:18015
    See related
    Ensembl:ENSG00000056736 MIM:605458; AllianceGenome:HGNC:18015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRL4; EVI27; IL17BR; IL17RH1
    Summary
    The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in kidney (RPKM 18.0), liver (RPKM 7.7) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3p21.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (53846568..53865794)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (53879806..53899034)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (53880595..53899821)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel subunit alpha1 D Neighboring gene uncharacterized LOC124906242 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:53750142-53751341 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53752305-53752885 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53752886-53753466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53765682-53766222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53766223-53766761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53787515-53788014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53798133-53798649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53802933-53803434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:53838519-53839320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53840931-53841432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53841433-53841932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53857324-53857923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53878721-53879561 Neighboring gene Sharpr-MPRA regulatory region 239 Neighboring gene choline dehydrogenase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14469 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:53925074-53925974 Neighboring gene actin related protein 8 Neighboring gene selenoprotein K Neighboring gene NANOG hESC enhancer GRCh37_chr3:54014583-54015161 Neighboring gene uncharacterized LOC105377095

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. IL17RB expression might predict prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer. Song Y, et al. Pathol Res Pract, 2019 Dec. PMID 31585811
    2. IL-17RB enhances thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression. Ren L, et al. Mol Immunol, 2017 Oct. PMID 28715683
    3. The T(H)2-polarizing function of atopic interleukin 17 receptor B-positive dendritic cells up-regulated by lipopolysaccharide. Zheng R, et al. Ann Allergy Asthma Immunol, 2017 Apr. PMID 28132739
    4. IL-17RB(+) granulocytes are associated with airflow obstruction in asthma. Li L, et al. Ann Allergy Asthma Immunol, 2016 Dec. PMID 27979026, Free PMC Article
    5. The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex. Hunninghake GM, et al. BMC Pulm Med, 2011 Apr 7. PMID 21473777, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRL4-DCAF8L2 E3 ligase promotes ubiquitination and degradation of BARD1.
      Title: CRL4-DCAF8L2 E3 ligase promotes ubiquitination and degradation of BARD1.
    2. IL-25 promotes trophoblast proliferation and invasion via binding with IL-17RB and associated with PE.
      Title: IL-25 promotes trophoblast proliferation and invasion via binding with IL-17RB and associated with PE.
    3. MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival.
      Title: MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival.
    4. IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination.
      Title: IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination.
    5. Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses.
      Title: Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses.
    6. An IMiD-induced SALL4 degron system for selective degradation of target proteins.
      Title: An IMiD-induced SALL4 degron system for selective degradation of target proteins.
    7. CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation.
      Title: CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation.
    8. IL17RB predicts the prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer.
      Title: IL17RB expression might predict prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer.
    9. Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.
      Title: Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.
    10. Using CRISPR-Cas9-mediated IL17RB-CreERT2 knockin human organoids, study showed that IL17RB marks human colorectal cancer stem cells by lineage tracing, and that long-term targeting of IL17RB+ cells strongly suppressed the tumor growth in vivo. This study identifies IL17RB+ cancer stem cells and preclinically validates them as a cancer therapeutic target.
      Title: Lineage tracing and targeting of IL17RB(+) tuft cell-like human colorectal cancer stem cells.
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC5245

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables interleukin-17 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-17 receptor B
    Names
    IL-17 receptor B
    IL-17 receptor homolog 1
    IL-17B receptor
    IL-17RB
    IL-17Rh1
    cytokine receptor CRL4
    cytokine receptor-like 4
    interleukin 17 receptor homolog 1
    interleukin-17B receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018725.4 → NP_061195.2  interleukin-17 receptor B precursor

      See identical proteins and their annotated locations for NP_061195.2

      Status: REVIEWED

      Source sequence(s)
      BC000980, DA093617
      Consensus CDS
      CCDS2874.1
      UniProtKB/Swiss-Prot
      Q9BPZ0, Q9NRL4, Q9NRM5, Q9NRM6
      Related
      ENSP00000288167.3, ENST00000288167.8
      Conserved Domains (3) summary
      pfam08357
      Location:332 → 479
      SEFIR; SEFIR domain
      pfam16556
      Location:33 → 175
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
      pfam16578
      Location:176 → 268
      IL17R_fnIII_D2; Interleukin 17 receptor D

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      53846568..53865794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      53879806..53899034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172234.1: Suppressed sequence

      Description
      NM_172234.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NRM6.2 GenPept UniProtKB/Swiss-Prot:Q9NRM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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