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    Sh2d1b1 SH2 domain containing 1B1 [ Mus musculus (house mouse) ]

    Gene ID: 26904, updated on 12-May-2024

    Summary

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    Official Symbol
    Sh2d1b1provided by MGI
    Official Full Name
    SH2 domain containing 1B1provided by MGI
    Primary source
    MGI:MGI:1349420
    See related
    Ensembl:ENSMUSG00000102418 AllianceGenome:MGI:1349420
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eat2; EAT-2; Eat2a; EAT-2A; Sh2d1b
    Summary
    Enables phosphotyrosine residue binding activity. Involved in leukocyte activation involved in immune response and positive regulation of natural killer cell mediated immunity. Acts upstream of or within several processes, including natural killer cell inhibitory signaling pathway; regulation of natural killer cell mediated cytotoxicity; and regulation of peptidyl-tyrosine phosphorylation. Orthologous to human SH2D1B (SH2 domain containing 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 2.2), spleen adult (RPKM 1.5) and 12 other tissues See more
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    Genomic context

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    Location:
    1 H3; 1 76.84 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170104887..170114338)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170277318..170286769)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 1B2 Neighboring gene STARR-seq mESC enhancer starr_02988 Neighboring gene STARR-seq mESC enhancer starr_02989 Neighboring gene STARR-positive B cell enhancer mm9_chr1:172185797-172186097 Neighboring gene predicted gene 6345 Neighboring gene predicted gene 7694 Neighboring gene spermatogenesis associated 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling. Talaei N, et al. J Immunol, 2015 Nov 15. PMID 26432891
    2. Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens. Aldhamen YA, et al. J Immunol, 2011 Jan 15. PMID 21149608
    3. EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. Thompson AD, et al. Oncogene, 1996 Dec 19. PMID 9000139
    4. CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. Tangye SG, et al. Eur J Immunol, 2002 Jun. PMID 12115647
    5. EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization. Pérez-Quintero LA, et al. J Exp Med, 2014 Apr 7. PMID 24687958, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EAT-2 negatively regulates cytokine production in dendritic cells downstream of SLAM engagement and a genetic polymorphism that disturbs this process promotes the development of lupus.
      Title: Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.
    2. EAT-2 mediates its effects in natural killer cells by linking SLAM family receptors to phospholipase Cgamma, calcium fluxes, and Erk kinase.
      Title: EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.
    3. EAT-2A and EAT-2B act as positive regulators of signaling lymphocyte activation molecule family receptor-specific NK cell functions in C57BL/6 mice.
      Title: Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse.
    4. EAT-2 mediates CRACC function. In the absence of EAT-2, CRACC inhibited natural killer cell function.
      Title: Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function.
    5. Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src kinases to SLAM family receptors using a mechanism that is distinct from that of SAP.
      Title: Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (6)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukocyte activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within natural killer cell inhibitory signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of natural killer cell mediated cytotoxicity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of natural killer cell mediated immunity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SH2 domain-containing protein 1B
    Names
    EWS/FLI1 activated transcript 2
    SH2 domain protein 1B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012009.5 → NP_036139.3  SH2 domain-containing protein 1B

      See identical proteins and their annotated locations for NP_036139.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
      Source sequence(s)
      AC123650, BC116698
      Consensus CDS
      CCDS35767.1
      UniProtKB/Swiss-Prot
      O35324, Q8C268
      UniProtKB/TrEMBL
      Q149T1, Q45GR7
      Related
      ENSMUSP00000137069.2, ENSMUST00000179976.3
      Conserved Domains (1) summary
      cd10342
      Location:1 → 103
      SH2_SAP1; Src homology 2 (SH2) domain found in SLAM-associated protein (SAP)1

    RNA

    1. NR_153837.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123650, BG146668

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      170104887..170114338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35324.1 GenPept UniProtKB/Swiss-Prot:O35324

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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