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    ZNF491 zinc finger protein 491 [ Homo sapiens (human) ]

    Gene ID: 126069, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ZNF491provided by HGNC
    Official Full Name
    zinc finger protein 491provided by HGNC
    Primary source
    HGNC:HGNC:23706
    See related
    Ensembl:ENSG00000177599 AllianceGenome:HGNC:23706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    Location:
    19p13.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11798523..11808503)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11926724..11936704)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11909338..11919318)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14032 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11849745-11849939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10130 Neighboring gene zinc finger protein 441 Neighboring gene uncharacterized LOC124904639 Neighboring gene MPRA-validated peak3359 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10131 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11908593-11909104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10133 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10134 Neighboring gene zinc finger protein 440 Neighboring gene vomeronasal 2 receptor 13 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Generation and analysis of 280,000 human expressed sequence tags. Hillier LD, et al. Genome Res, 1996 Sep. PMID 8889549
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ34791, MGC126639, MGC126641

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 491

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152356.4 → NP_689569.2  zinc finger protein 491

      See identical proteins and their annotated locations for NP_689569.2

      Status: VALIDATED

      Source sequence(s)
      AA083980, AC008543, BC101590, DA776617
      Consensus CDS
      CCDS12267.1
      UniProtKB/Swiss-Prot
      Q3MJ35, Q8N8L2, Q8NAT8
      Related
      ENSP00000313443.5, ENST00000323169.10
      Conserved Domains (2) summary
      COG5048
      Location:50 → 290
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:161 → 181
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11798523..11808503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438144.1 → XP_047294100.1  zinc finger protein 491 isoform X1

      UniProtKB/Swiss-Prot
      Q3MJ35, Q8N8L2, Q8NAT8

    2. XM_005259730.5 → XP_005259787.1  zinc finger protein 491 isoform X1

      See identical proteins and their annotated locations for XP_005259787.1

      UniProtKB/Swiss-Prot
      Q3MJ35, Q8N8L2, Q8NAT8
      Conserved Domains (2) summary
      COG5048
      Location:50 → 290
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:161 → 181
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      11926724..11936704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319753.1 → XP_054175728.1  zinc finger protein 491 isoform X1

      UniProtKB/Swiss-Prot
      Q3MJ35, Q8N8L2, Q8NAT8

    2. XM_054319754.1 → XP_054175729.1  zinc finger protein 491 isoform X1

      UniProtKB/Swiss-Prot
      Q3MJ35, Q8N8L2, Q8NAT8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N8L2.1 GenPept UniProtKB/Swiss-Prot:Q8N8L2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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