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heparinase II/III family protein
This family features sequences that are similar to a region of the Flavobacterium heparinum proteins heparinase II (Swiss:Q46080) and heparinase III (Swiss:Q59289). The former is known to degrade heparin and heparin sulphate, whereas the latter predominantly degrades heparin sulphate. Both are secreted into the periplasmic space upon induction with heparin [1]. [1]. 8702264. Isolation and expression in Escherichia coli of hepB and hepC,. genes coding for the glycosaminoglycan-degrading enzymes. heparinase II and heparinase III, respectively, from. Flavobacterium heparinum.. Su H, Blain F, Musil RA, Zimmermann JJ, Gu K, Bennett DC;. Appl Environ Microbiol 1996;62:2723-2734.. [2]. 23011846. Structural basis of heparan sulfate-specific degradation by. heparinase III.. Dong W, Lu W, McKeehan WL, Luo Y, Ye S;. Protein Cell. 2012;3:950-961. (from Pfam)
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