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1.
Figure 1

Figure 1. From: Quantitation of HER2/neu Expression in Primary Gastroesophageal Adenocarcinomas Using Conventional Light Microscopy and Quantitative Image Analysis.

Examples of quantitative human epidermal growth factor receptor 2 (HER2/neu) immunohistochemistry (IHC) scoring in gastroesophageal specimens based on consensus guidelines. A, Gastric adenocarcinoma specimen with HER2/neu IHC score of 0. B, Gastric adenocarcinoma specimen demonstrating HER2/neu IHC 1+ score. C, Example of gastric adenocarcinoma displaying HER2/neu IHC 2+ score. D, Gastroesophageal junction adenocarcinoma specimen demonstrating HER2/neu overexpression (IHC 3+) (HER2/neu IHC stain [HercepTest, Dako, Carpinteria, California], original magnifications ×400 [A through D]).

Jennifer Jeung, et al. Arch Pathol Lab Med. ;136(6):610-617.

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2.
Figure 2

Figure 2. From: Quantitation of HER2/neu Expression in Primary Gastroesophageal Adenocarcinomas Using Conventional Light Microscopy and Quantitative Image Analysis.

Example of a case with discordance between manual human epidermal growth factor receptor 2 (HER2/neu) immunohistochemistry (IHC) score and HER2/neu image analysis interpretation. A, Biopsy specimen of gastroesophageal junction adenocarcinoma. B, The tumor demonstrates scattered tumor clusters (>5 cells) with HER2/neu IHC 3+ staining, which would be considered overexpression in this biopsy sample. The Automated Cellular Imaging System III (ACIS III) image analysis HER2/neu value was 1.2, which corresponds to a negative interpretation (hematoxylin-eosin, original magnification ×400 [A]; HER2/neu IHC stain [HercepTest, Dako, Carpinteria, California], original magnification × 200 [B]).

Jennifer Jeung, et al. Arch Pathol Lab Med. ;136(6):610-617.

CitationFull text

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