PMC

Schematic representation of time epoch comparisons for the study. B1 represents the first baseline; upon viewing of a the video, a button press by the individual indicates the onset of an emotional or motivational response ( ); E0 represents the epoch prior to the button press; E1 represents the epoch immediately following the button press; E2 represents the final period of the video viewing. Horizontal bar lines represent comparisons between different epochs

Functional magnetic resonance image correlational map of pathological gambling (PG) subjects (n = 10) after the reported onset of emotional or motivational response (E1–E0) during viewing of the Gambling (a, b), Sad (c), and Happy (d) scenarios. a Brain activation maps (z = −12) show positive correlations between the intensity of subjective reports of gambling motivations and bilateral temporal pole (TP) activity. b Brain activation maps (z = −12) show positive correlations between the intensity of subjective reports of gambling emotions and bilateral TP activity. c Brain activation map (z = −12) shows correlations between the intensity of subjective reports of sadness and brain activity in the orbitofrontal cortex (OFC), the right hippocampus (Hi) and parahippocampal gyrus (Ph) and the left medial temporal gyrus (MT) during viewing of the sad scenarios. d Brain activation map (z = −4) for the happy scenario show negative correlations between the intensity of subjective reports of happiness and brain activity in the left superior frontal gyrus (GFs), the left middle temporal gyrus (GTm), the right TP and the right Ph. Map displays correlations >0.7, with an extent threshold of 25 voxels. Blue/purple color indicates areas displaying inverse correlations and red/yellow color indicates areas displaying positive correlations. The left side of the brain is displayed on the right side of each image