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Select item 108295221.

BRD4 Regulates Glycolysis-Dependent Nos2 Expression in Macrophages Upon H pylori Infection

Nikita Modi, Yanheng Chen, Xingchen Dong, Xiangming Hu, Gee W. Lau, Keith T. Wilson, Richard M. Peek, Jr., Lin-Feng Chen

Cell Mol Gastroenterol Hepatol. 2024; 17(2): 292–308.e1. Published online 2023 Oct 10. doi: 10.1016/j.jcmgh.2023.10.001

PMCID:: PMC10829522

Article PDF–2.1M

Select item 104874932.

BRD4 Inhibition Enhances the Antitumor Effects of Radiation Therapy in a Murine Breast Cancer Model

Seongmin Kim, Seung Hyuck Jeon, Min Guk Han, Mi Hyun Kang, In Ah Kim

Int J Mol Sci. 2023 Sep; 24(17): 13062. Published online 2023 Aug 22. doi: 10.3390/ijms241713062

PMCID:: PMC10487493

Article PDF–4.4M

Select item 97469083.

Ox40-Cre–mediated deletion of BRD4 reveals an unexpected phenotype of hair follicle stem cells in alopecia

Mou Wen, Yuanlin Ying, Xiang Xiao, Preston R. Arnold, Guangchuan Wang, Xiufeng Chu, Rafik M. Ghobrial, Xian C. Li

JCI Insight. 2022 Dec 8; 7(23): e164534. Published online 2022 Dec 8. doi: 10.1172/jci.insight.164534

PMCID:: PMC9746908

Article PDF–23M

Select item 90142084.

Brd4 is required for chondrocyte differentiation and endochondral ossification

Christopher R. Paradise, M. Lizeth Galvan, Oksana Pichurin, Sofia Jerez, Eva Kubrova, S. Sharare Dehghani, Margarita E. Carrasco, Roman Thaler, A. Noelle Larson, Andre J. van Wijnen, Amel Dudakovic

Bone. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Bone. 2022 Jan; 154: 116234. Published online 2021 Oct 23. doi: 10.1016/j.bone.2021.116234

PMCID:: PMC9014208

Article PDF–2.0M

Select item 85913645.

The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains

Jocelyn D. Weissman, Amit K. Singh, Ballachanda N. Devaiah, Peter Schuck, Ross C. LaRue, Dinah S. Singer

J Biol Chem. 2021 Nov; 297(5): 101326. Published online 2021 Oct 22. doi: 10.1016/j.jbc.2021.101326

PMCID:: PMC8591364

Article PDF–2.5M

Select item 85298306.

Inhibition of BRD4 inhibits proliferation and promotes apoptosis of psoriatic keratinocytes

Xiaohui Sun, Pengfei Yang

Biomed Eng Online. 2021; 20: 107. Published online 2021 Oct 21. doi: 10.1186/s12938-021-00943-y

PMCID:: PMC8529830

Article PDF–3.2M

Select item 84277567.

Brd4 Regulates the Homeostasis of CD8⁺ T-Lymphocytes and Their Proliferation in Response to Antigen Stimulation

Zhilin Peng, Yiwen Zhang, Xiancai Ma, Mo Zhou, Shiyu Wu, Zheng Song, Yaochang Yuan, Yingshi Chen, Yuzhuang Li, Guanwen Wang, Feng Huang, Yidan Qiao, Baijing Xia, Weiwei Liu, Jun Liu, Xu Zhang, Xin He, Ting Pan, Hanshi Xu, Hui Zhang

Front Immunol. 2021; 12: 728082. Published online 2021 Aug 26. doi: 10.3389/fimmu.2021.728082

PMCID:: PMC8427756

Article PDF–6.8M

Select item 81605758.

Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection

J. Justin Milner, Clara Toma, Sara Quon, Kyla Omilusik, Nicole E. Scharping, Anup Dey, Miguel Reina-Campos, Hongtuyet Nguyen, Adam J. Getzler, Huitian Diao, Bingfei Yu, Arnaud Delpoux, Tomomi M. Yoshida, Deyao Li, Jun Qi, Adam Vincek, Stephen M. Hedrick, Takeshi Egawa, Ming-Ming Zhou, Shane Crotty, Keiko Ozato, Matthew E. Pipkin, Ananda W. Goldrath

J Exp Med. 2021 Aug 2; 218(8): e20202512. Published online 2021 May 26. doi: 10.1084/jem.20202512

PMCID:: PMC8160575

Article PDF–4.8M

Select item 77363249.

Epigenetic Reader BRD4 Governs Nucleus-encoded Mitochondrial Transcriptome to Regulate Cardiac Function

Soo Young Kim, Xin Zhang, Gabriele G. Schiattarella, Francisco Altamirano, Thais A. R. Ramos, Kristin M. French, Nan Jiang, Pamela A. Szweda, Bret M. Evers, Herman I. May, Xiang Luo, Hongliang Li, Luke I. Szweda, Vinicius Maracaja-Coutinho, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill

Circulation. Author manuscript; available in PMC 2021 Dec 15.

Published in final edited form as: Circulation. 2020 Dec 15; 142(24): 2356–2370. Published online 2020 Oct 28. doi: 10.1161/CIRCULATIONAHA.120.047239

PMCID:: PMC7736324

Article PDF–2.4M

Select item 731034710.

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation

Matthew S. Stratton, Rushita A. Bagchi, Marina B. Felisbino, Rachel A. Hirsch, Harrison E. Smith, Andrew S. Riching, Blake Y. Enyart, Keith A. Koch, Maria A. Cavasin, Michael Alexanian, Kunhua Song, Jun Qi, Madeleine E. Lemieux, Deepak Srivastava, Maggie P.Y. Lam, Saptarsi M. Haldar, Charles Y. Lin, Timothy A. McKinsey

Circ Res. Author manuscript; available in PMC 2020 Sep 13.

Published in final edited form as: Circ Res. 2019 Sep 13; 125(7): 662–677. Published online 2019 Aug 14. doi: 10.1161/CIRCRESAHA.119.315125

PMCID:: PMC7310347

Article PDF–3.6M

Select item 666443711.

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription

Vivek Behera, Aaron J. Stonestrom, Nicole Hamagami, Chris C. Hsiung, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Zuo-Fei Yuan, Natarajan V. Bhanu, Michael T. Werner, Hongxin Wang, Benjamin A. Garcia, Ross C. Hardison, Gerd A. Blobel

Cell Rep. Author manuscript; available in PMC 2019 Jul 30.

Published in final edited form as: Cell Rep. 2019 Apr 9; 27(2): 400–415.e5. doi: 10.1016/j.celrep.2019.03.057

PMCID:: PMC6664437

Article PDF–2.6M

Select item 665821912.

Mice with a Brd4 Mutation Represent a New Model of Nephrocalcinosis

Caroline M Gorvin, Nellie Y Loh, Michael J Stechman, Sara Falcone, Fadil M Hannan, Bushra N Ahmad, Sian E Piret, Anita AC Reed, Jeshmi Jeyabalan, Paul Leo, Mhairi Marshall, Siddharth Sethi, Paul Bass, Ian Roberts, Jeremy Sanderson, Sara Wells, Tertius A Hough, Liz Bentley, Paul T Christie, Michelle M Simon, Ann‐Marie Mallon, Herbert Schulz, Roger D Cox, Matthew A Brown, Norbert Huebner, Steve D Brown, Rajesh V Thakker

J Bone Miner Res. 2019 Jul; 34(7): 1324–1335. Published online 2019 Mar 4. doi: 10.1002/jbmr.3695

PMCID:: PMC6658219

Article PDF–453K

Select item 644320713.

BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses

Anup Dey, Wenjing Yang, Anne Gegonne, Akira Nishiyama, Richard Pan, Ryoji Yagi, Alex Grinberg, Fred D Finkelman, Karl Pfeifer, Jinfang Zhu, Dinah Singer, Jun Zhu, Keiko Ozato

EMBO J. 2019 Apr 1; 38(7): e100293. Published online 2019 Mar 6. doi: 10.15252/embj.2018100293

PMCID:: PMC6443207

Article PDF–1.6M

Select item 629874514.

Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation

Anne Gegonne, Qing-Rong Chen, Anup Dey, Ruth Etzensperger, Xuguang Tai, Alfred Singer, Daoud Meerzaman, Keiko Ozato, Dinah S. Singer

Cell Rep. Author manuscript; available in PMC 2018 Dec 18.

Published in final edited form as: Cell Rep. 2018 Jul 3; 24(1): 117–129. doi: 10.1016/j.celrep.2018.06.007

PMCID:: PMC6298745

Article PDF–2.6M

Select item 483849915.

BET bromodomain inhibition releases the Mediator complex from select cis-regulatory elements

Anand S. Bhagwat, Jae-Seok Roe, Beverly A. Mok, Anja F. Hohmann, Junwei Shi, Christopher R. Vakoc

Cell Rep. Author manuscript; available in PMC 2016 Apr 20.

Published in final edited form as: Cell Rep. 2016 Apr 19; 15(3): 519–530. Published online 2016 Apr 7. doi: 10.1016/j.celrep.2016.03.054

PMCID:: PMC4838499

Article PDF–1.9M

Select item 475212016.

BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

Erica Korb, Margo Herre, Ilana Zucker-Scharff, Robert B. Darnell, C. David Allis

Nat Neurosci. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Nat Neurosci. 2015 Oct; 18(10): 1464–1473. Published online 2015 Aug 24. doi: 10.1038/nn.4095

PMCID:: PMC4752120

Article PDF–2.9M

Select item 474098817.

Histone H4 acetylation and the epigenetic reader Brd4 are critical regulators of pluripotency in embryonic stem cells

Michelle Gonzales-Cope, Simone Sidoli, Natarajan V. Bhanu, Kyoung-Jae Won, Benjamin A. Garcia

BMC Genomics. 2016; 17: 95. Published online 2016 Feb 4. doi: 10.1186/s12864-016-2414-y

PMCID:: PMC4740988

Article PDF–2.3M

Select item 472098318.

BRD4 assists elongation of both coding and enhancer RNAs guided by histone acetylation

Tomohiko Kanno, Yuka Kanno, Gary LeRoy, Eric Campos, Hong-Wei Sun, Stephen R Brooks, Golnaz Vahedi, Tom D Heightman, Benjamin A Garcia, Danny Reinberg, Ulrich Siebenlist, John J O’Shea, Keiko Ozato

Nat Struct Mol Biol. Author manuscript; available in PMC 2016 Jan 21.

Published in final edited form as: Nat Struct Mol Biol. 2014 Dec; 21(12): 1047–1057. Published online 2014 Nov 10. doi: 10.1038/nsmb.2912

PMCID:: PMC4720983

Article PDF–3.4M

Select item 469741719.

BRD4 is a novel therapeutic target for liver fibrosis

Ning Ding, Nasun Hah, Ruth T. Yu, Mara H. Sherman, Chris Benner, Mathias Leblanc, Mingxiao He, Christopher Liddle, Michael Downes, Ronald M. Evans

Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51): 15713–15718. Published online 2015 Dec 7. doi: 10.1073/pnas.1522163112

PMCID:: PMC4697417

Article PDF–1.5M

Select item 447548920.

BET bromodomain inhibition suppresses the functional output of hematopoietic transcription factors in acute myeloid leukemia

Jae-Seok Roe, Fatih Mercan, Keith Rivera, Darryl J. Pappin, Christopher R. Vakoc

Mol Cell. Author manuscript; available in PMC 2016 Jun 18.

Published in final edited form as: Mol Cell. 2015 Jun 18; 58(6): 1028–1039. Published online 2015 May 14. doi: 10.1016/j.molcel.2015.04.011

PMCID:: PMC4475489

Article PDF–2.0M

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