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Select item 66975841.

A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling

Yujie Huang, Jiansong Fang, Weiqiang Lu, Zihao Wang, Qi Wang, Yuan Hou, Xingwu Jiang, Ofer Reizes, Justin Lathia, Ruth Nussinov, Charis Eng, Feixiong Cheng

Cell Chem Biol. Author manuscript; available in PMC 2020 Aug 15.

Published in final edited form as: Cell Chem Biol. 2019 Aug 15; 26(8): 1143–1158.e6. Published online 2019 Jun 6. doi: 10.1016/j.chembiol.2019.05.004

PMCID:: PMC6697584

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Wogonoside induces depalmitoylation and translocation of PLSCR1 and N‐RAS in primary acute myeloid leukaemia cells

Hui Li, Xiaoxuan Yu, Xiao Liu, Po Hu, Le Shen, Yuxin Zhou, Yu Zhu, Zhiyu Li, Hui Hui, Qinglong Guo, Jingyan Xu

J Cell Mol Med. 2018 Apr; 22(4): 2117–2130. Published online 2018 Jan 29. doi: 10.1111/jcmm.13481

PMCID:: PMC5867108

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Select item 55207003.

PLSCR1/IP3R1/Ca²⁺ axis contributes to differentiation of primary AML cells induced by wogonoside

Hui Li, Jingyan Xu, Yuxin Zhou, Xiao Liu, L e Shen, Y u Zhu, Zhiyu Li, Xiaotang Wang, Qinglong Guo, Hui Hui

Cell Death Dis. 2017 May; 8(5): e2768. Published online 2017 May 11. doi: 10.1038/cddis.2017.175

PMCID:: PMC5520700

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Select item 55435474.

Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer

Yuyuan Yao, Kai Zhao, Zhou Yu, Haochuan Ren, Li Zhao, Zhiyu Li, Qinglong Guo, Na Lu

J Exp Clin Cancer Res. 2017; 36: 103. Published online 2017 Aug 3. doi: 10.1186/s13046-017-0574-5

Correction in:: J Exp Clin Cancer Res. 2019; 38: 444.

PMCID:: PMC5543547

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Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway

Yang Sun, Yue Zhao, Xiaoping Wang, Li Zhao, Wenjun Li, Youxiang Ding, Lingyi Kong, Qinglong Guo, Na Lu

Oncotarget. 2016 Jun 7; 7(23): 34300–34315. Published online 2016 Apr 18. doi: 10.18632/oncotarget.8815

PMCID:: PMC5085157

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Effects of wogonoside on the inflammatory response and oxidative stress in mice with nonalcoholic fatty liver disease

Guangyu Jiang, Dayin Chen, Wenpeng Li, Chengcheng Liu, Jiguang Liu, Yingxue Guo

Pharm Biol. 2020; 58(1): 1186–1192. Published online 2020 Nov 30. doi: 10.1080/13880209.2020.1845747

PMCID:: PMC7875554

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Wogonoside induces cell cycle arrest and mitochondrial mediated apoptosis by modulation of Bcl-2 and Bax in osteosarcoma cancer cells

Yang Wang, Ruo-Feng Yin, Jia-Song Teng

Int J Clin Exp Pathol. 2015; 8(1): 63–72. Published online 2015 Jan 1.

PMCID:: PMC4348927

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Deglycosylation of wogonoside enhances its anticancer potential

Chong-Zhi Wang, Jin-Yi Wan, Chun-Feng Zhang, Fang Lu, Lina Chen, Chun-Su Yuan

J Cancer Res Ther. Author manuscript; available in PMC 2018 Sep 27.

Published in final edited form as: J Cancer Res Ther. 2018 Sep; 14(Suppl): S594–S599. doi: 10.4103/0973-1482.183218

PMCID:: PMC6159225

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Treatment of Brain Edema by Wogonoside Is Associated with Inhibition of Neuronal Apoptosis and SIRT1 Activation in Rats

Yingqiu Cheng, Shipeng Li, Yi Liu, Jinghui Li, Ye Chen, Hexiang Zhao

Med Sci Monit. 2020; 26: e921250-1–e921250-8. Prepublished online 2020 Feb 3. Published online 2020 Mar 28. doi: 10.12659/MSM.921250

PMCID:: PMC7133416

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Development and validation of an LC-MS/MS method for the quantification of flavonoid glucuronides (wogonoside, baicalin, and apigenin-glucuronide) in the bile and blood samples: Application to a portal vein infusion study

Yifan Tu, Lei Zhou, Li Li, Lu Wang, Song Gao, Ming Hu

Anal Biochem. Author manuscript; available in PMC 2022 Jul 27.

Published in final edited form as: Anal Biochem. 2020 Jul 15; 601: 113723. Published online 2020 Apr 13. doi: 10.1016/j.ab.2020.113723

PMCID:: PMC9326899

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Pretreatment of baicalin and wogonoside with glycoside hydrolase: A promising approach to enhance anticancer potential

CHUNHAO YU, ZHIYU ZHANG, HAIJIANG ZHANG, ZHONG ZHEN, TYLER CALWAY, YUNWEI WANG, CHUN-SU YUAN, CHONG-ZHI WANG

Oncol Rep. 2013 Nov; 30(5): 2411–2418. Published online 2013 Sep 9. doi: 10.3892/or.2013.2726

PMCID:: PMC3820585

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Select item 665150912.

Comparative Investigation for Rotten Xylem (kuqin) and Strip Types (tiaoqin) of Scutellaria baicalensis Georgi Based on Fingerprinting and Chemical Pattern Recognition

Xuexiao Cao, Guangjiao You, Huanhuan Li, Di Li, Meng Wang, Xiaoliang Ren

Molecules. 2019 Jul; 24(13): 2431. Published online 2019 Jul 2. doi: 10.3390/molecules24132431

PMCID:: PMC6651509

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汉黄芩苷通过上调SIRT1表达减轻糖尿病视网膜病变引起的细胞和组织损伤

邵晓丽, 余江毅, 倪卫惠

Nan Fang Yi Ke Da Xue Xue Bao. 2022 Apr 20; 42(4): 463–472. Chinese. doi: 10.12122/j.issn.1673-4254.2022.04.02

PMCID:: PMC9085582

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Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-κB, and STAT3

Amer Ali Abd El-Hafeez, Hazim O. Khalifa, Elham A. M. Mahdy, Vikas Sharma, Toru Hosoi, Pradipta Ghosh, Koichiro Ozawa, Monica M. Montano, Takashi Fujimura, Ahmed R. N. Ibrahim, Mohamed A. A. Abdelhamid, Seung Pil Pack, Samia A. Shouman, Seiji Kawamoto

Pharmacol Rep. Author manuscript; available in PMC 2019 May 28.

Published in final edited form as: Pharmacol Rep. 2019 Apr; 71(2): 289–298. Published online 2019 Jan 7. doi: 10.1016/j.pharep.2019.01.001

PMCID:: PMC6536637

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Comparative Study of the Effect of Baicalin and Its Natural Analogs on Neurons with Oxygen and Glucose Deprivation Involving Innate Immune Reaction of TLR2/TNFα

Hui-Ying Li, Jun Hu, Shuang Zhao, Zhi-Yi Yuan, Hong-Jiao Wan, Fan Lei, Yi Ding, Dong-Ming Xing, Li-Jun Du

J Biomed Biotechnol. 2012; 2012: 267890. Published online 2012 Mar 21. doi: 10.1155/2012/267890

PMCID:: PMC3321472

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Select item 530016916.

Bifunctional effects of O-methylated flavones from Scutellaria baicalensis Georgi on melanocytes: Inhibition of melanin production and intracellular melanosome transport

Michiko Kudo, Kumiko Kobayashi-Nakamura, Kentaro Tsuji-Naito

PLoS One. 2017; 12(2): e0171513. Published online 2017 Feb 9. doi: 10.1371/journal.pone.0171513

PMCID:: PMC5300169

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Rapid Isolation and Determination of Flavones in Biological Samples Using Zinc Complexation Coupled with High-Performance Liquid Chromatography

Chenghe Sun, Hecheng Wang, Yingping Wang, Shengyuan Xiao

Molecules. 2016 Aug; 21(8): 1067. Published online 2016 Aug 16. doi: 10.3390/molecules21081067

PMCID:: PMC6274430

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Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis

Chunhao Yu, Fengyun Qu, Yanyong Mao, Dong Li, Zhong Zhen, Rachael Nass, Tyler Calway, Yunwei Wang, Chun-Su Yuan, Chong-Zhi Wang

Pharm Biol. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Pharm Biol. 2013 Oct; 51(10): 1228–1235. Published online 2013 Jun 5. doi: 10.3109/13880209.2013.784922

PMCID:: PMC3971064

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Select item 755366819.

Wogonoside Attenuates Cutaneous Squamous Cell Carcinoma by Reducing Epithelial–Mesenchymal Transition/Invasion and Cancer Stem-Like Cell Property

Xiuyong Wang, Yuan Chang, Ming Gao, Fan Zhang

Onco Targets Ther. 2020; 13: 10097–10109. Published online 2020 Oct 9. doi: 10.2147/OTT.S251806

PMCID:: PMC7553668

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Select item 793844620.

Wogonoside promotes apoptosis and ER stress in human gastric cancer cells by regulating the IRE1α pathway

Qian Gu, Canhong Zhu, Xi Wu, Lianghuan Peng, Genya Huang, Rong Hu

Exp Ther Med. 2021 Apr; 21(4): 411. Published online 2021 Feb 25. doi: 10.3892/etm.2021.9842

PMCID:: PMC7938446

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Figure 11Potential molecular mechanism involved in wogonoside treatment in chondrocytes

Wogonoside attenuated IL-1β induced ECM degradation and hypertrophy in mice chondrocyte via suppressing NF-Κb/ HIF-2α activation by PI3K/Akt pathway.

Wogonoside inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocyte and ameliorates murine osteoarthritis

Oncotarget. 2017 Sep 5;8(37):61440-61456.
Figure 2Effects of wogonoside on the cell viability of chondrocytes

(A) Chemical structure of wogonoside. (B) The cytotoxic effect of wogonoside on chondrocytes was determined at various concentrations for 24 and 48 hours using a CCK8 assay. The values presented are the means ± S.D. of three independent experiments. *P < 0.05, **P < 0.01 vs. control group.

Wogonoside inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocyte and ameliorates murine osteoarthritis

Oncotarget. 2017 Sep 5;8(37):61440-61456.
Figure 1

Wogonoside decreases cell viability of AGS cells and MKN-45 cells. (A) Molecular structure of wogonoside. The AGS and MKN-45 cell lines were treated with (B and C) different concentrations of wogonoside and at (D and E) different periods of time. (F) GES-1 cells were exposed to different concentrations of wogonoside for 48 h. Cell viability (B, C, D and E) and apoptosis (G, H and I) were evaluated using Cell Counting Kit-8 assay and Annexin V staining, respectively in the AGS, MKN-45 and GES-1 cell lines. ^*P<0.05, ^**P<0.01, ^***P<0.001, ^****P<0.0001, ^nsP>0.05. Wog, wogonoside; NS, non-significant.

Wogonoside promotes apoptosis and ER stress in human gastric cancer cells by regulating the IRE1α pathway

Exp Ther Med. 2021 Apr;21(4):411.
Figure 2

Effect of wogonoside on brain edema and Evans blue extravasation in SAH rats. (A) Brain water content in SAH-induced rats pre-treated with various doses of wogonoside. (B) Changes in Evans blue extravasation in SAH-induced rats with wogonoside pre-treatment. * P<0.05, ** P<0.02 and *** P<0.01 vs. Sham group.

Treatment of Brain Edema by Wogonoside Is Associated with Inhibition of Neuronal Apoptosis and SIRT1 Activation in Rats

Med Sci Monit. 2020;26:e921250-1-e921250-8.