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Select item 102432731.

Translatability scoring in prospective and retrospective COVID drug development cases

Alexandra Wendler, Martin Wehling

Eur J Clin Pharmacol. 2023; 79(8): 1051–1071. Published online 2023 Jun 6. doi: 10.1007/s00228-023-03517-0

PMCID:: PMC10243273

Article PDF–858K

Select item 49228182.

Cultural adaptation: translatability assessment and linguistic validation of the patient-reported outcome instrument for irritable bowel syndrome with diarrhea

Leticia Delgado-Herrera, Kathryn Lasch, Ana Popielnicki, Akito Nishida, Rob Arbuckle, Benjamin Banderas, Susan Zentner, Ingrid Gagainis, Bernhardt Zeiher

Patient Relat Outcome Meas. 2016; 7: 81–92. Published online 2016 Jun 22. doi: 10.2147/PROM.S102647

PMCID:: PMC4922818

Article PDF–205K

Select item 49069063.

Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein

Victoria L. M. Herrera, Martin Steffen, Ann Marie Moran, Glaiza A. Tan, Khristine A. Pasion, Keith Rivera, Darryl J. Pappin, Nelson Ruiz-Opazo

BMC Mol Biol. 2016; 17: 15. Published online 2016 Jun 14. doi: 10.1186/s12867-016-0066-8

PMCID:: PMC4906906

Article PDF–3.5M

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Preclinical Neuropathic Pain Assessment; the Importance of Translatability and Bidirectional Research

Amy S. Fisher, Michael T. Lanigan, Neil Upton, Lisa A. Lione

Front Pharmacol. 2020; 11: 614990. Published online 2021 Feb 8. doi: 10.3389/fphar.2020.614990

PMCID:: PMC7897667

Article PDF–1.8M

Select item 56705165.

Translatability score revisited: differentiation for distinct disease areas

Alexandra Wendler, Martin Wehling

J Transl Med. 2017; 15: 226. Published online 2017 Nov 3. doi: 10.1186/s12967-017-1329-y

PMCID:: PMC5670516

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Select item 99439006.

Untranslated regions of brain-derived neurotrophic factor mRNA control its translatability and subcellular localization

Ingrid Lekk, Florencia Cabrera-Cabrera, Giorgio Turconi, Jürgen Tuvikene, Eli-Eelika Esvald, Annika Rähni, Laoise Casserly, Daniel R. Garton, Jaan-Olle Andressoo, Tõnis Timmusk, Indrek Koppel

J Biol Chem. 2023 Feb; 299(2): 102897. Published online 2023 Jan 11. doi: 10.1016/j.jbc.2023.102897

PMCID:: PMC9943900

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Points of View and Readers’ Immersion in Translation: A Neurocognitive Interpretation of Poetic Translatability

Qing Chen, Lin Shen, Shelley Ochs, Kairong Xiao

Front Psychol. 2022; 13: 877150. Published online 2022 May 6. doi: 10.3389/fpsyg.2022.877150

PMCID:: PMC9121805

Article PDF–384K

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Translatability Analysis of National Institutes of Health–Funded Biomedical Research That Applies Artificial Intelligence

Feyisope R. Eweje, Suzie Byun, Rajat Chandra, Fengling Hu, Ihab Kamel, Paul Zhang, Zhicheng Jiao, Harrison X. Bai

JAMA Netw Open. 2022 Jan; 5(1): e2144742. Published online 2022 Jan 24. doi: 10.1001/jamanetworkopen.2021.44742

PMCID:: PMC8787619

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Select item 59350179.

Emerging good practices for Translatability Assessment (TA) of Patient-Reported Outcome (PRO) measures

Catherine Acquadro, Donald L. Patrick, Sonya Eremenco, Mona L. Martin, Dagmara Kuliś, Helena Correia, Katrin Conway, on behalf of the International Society for Quality of Life Research (ISOQOL) Translation and Cultural Adaptation Special Interest Group (TCA-SIG)

J Patient Rep Outcomes. 2018 Dec; 2: 8. Published online 2018 Feb 21. doi: 10.1186/s41687-018-0035-8

PMCID:: PMC5935017

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Translatability scoring in drug development: eight case studies

Alexandra Wendler, Martin Wehling

J Transl Med. 2012; 10: 39. Published online 2012 Mar 7. doi: 10.1186/1479-5876-10-39

PMCID:: PMC3330010

Article PDF–355K

Select item 384686311.

Assessing the translatability of In vivo cardiotoxicity mechanisms to In vitro models using causal reasoning

Ahmed E Enayetallah, Dinesh Puppala, Daniel Ziemek, James E Fischer, Sheila Kantesaria, Mathew T Pletcher

BMC Pharmacol Toxicol. 2013; 14: 46. Published online 2013 Sep 6. doi: 10.1186/2050-6511-14-46

PMCID:: PMC3846863

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Select item 733644712.

Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

Henrik H. Hansen, Helene M. Ægidius, Denise Oró, Simon S. Evers, Sara Heebøll, Peter Lykke Eriksen, Karen Louise Thomsen, Anja Bengtsson, Sanne S. Veidal, Michel Feigh, Malte P. Suppli, Filip K. Knop, Henning Grønbæk, Diego Miranda, James L. Trevaskis, Niels Vrang, Jacob Jelsing, Kristoffer T. G. Rigbolt

BMC Gastroenterol. 2020; 20: 210. Published online 2020 Jul 6. doi: 10.1186/s12876-020-01356-2

PMCID:: PMC7336447

Article PDF–1.8M

Select item 785550913.

Hybridizing clinical translatability with enzyme-free DNA signal amplifiers: recent advances in nucleic acid detection and imaging

Raina M. Borum, Jesse V. Jokerst

Biomater Sci. Author manuscript; available in PMC 2022 Jan 21.

Published in final edited form as: Biomater Sci. 2021 Jan 21; 9(2): 347–366. Published online 2020 Jul 31. doi: 10.1039/d0bm00931h

PMCID:: PMC7855509

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Select item 635434114.

Translatability and validation of non-technical skills scale for trauma (T-NOTECHS) for assessing simulated multi-professional trauma team resuscitations

Jussi P. Repo, Eerika Rosqvist, Seppo Lauritsalo, Juha Paloneva

BMC Med Educ. 2019; 19: 40. Published online 2019 Jan 30. doi: 10.1186/s12909-019-1474-5

PMCID:: PMC6354341

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Select item 904548915.

The Functionality and Translatability of Neocartilage Constructs are Improved with the Combination of Fluid-Induced Shear Stress and Bioactive Factors

Evelia Y. Salinas, Ryan P. Donahue, Jessica M. Herrera, Jerry C. Hu, Kyriacos A. Athanasiou

FASEB J. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: FASEB J. 2022 Apr; 36(4): e22225. doi: 10.1096/fj.202101699R

PMCID:: PMC9045489

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Noble gases as cardioprotectants – translatability and mechanism

Kirsten F Smit, Nina C Weber, Markus W Hollmann, Benedikt Preckel

Br J Pharmacol. 2015 Apr; 172(8): 2062–2073. Published online 2015 Jan 12. doi: 10.1111/bph.12994

PMCID:: PMC4386981

Article PDF–741K

Select item 420629417.

Investigation of Cross-Species Translatability of Pharmacological MRI in Awake Nonhuman Primate - A Buprenorphine Challenge Study

Stephanie Seah, Abu Bakar Ali Asad, Richard Baumgartner, Dai Feng, Donald S. Williams, Elaine Manigbas, John D. Beaver, Torsten Reese, Brian Henry, Jeffrey L. Evelhoch, Chih-Liang Chin

PLoS One. 2014; 9(10): e110432. Published online 2014 Oct 22. doi: 10.1371/journal.pone.0110432

PMCID:: PMC4206294

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Rvb1/Rvb2 proteins couple transcription and translation during glucose starvation

Yang S Chen, Wanfu Hou, Sharon Tracy, Alex T Harvey, Vince Harjono, Fan Xu, James J Moresco, John R Yates, III, Brian M Zid

eLife. 2022; 11: e76965. Published online 2022 Sep 15. doi: 10.7554/eLife.76965

PMCID:: PMC9531950

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Select item 1035433119.

Translating primary care to telehealth: analysis of in-person consultations on diabetes and cardiovascular disease

Jared Lane, Katrina David, Jayashanthi Ramarao, Kanesha Ward, Sunayana Raghuraman, Moomna Waheed, Annie YS Lau

BJGP Open. 2023 Mar; 7(1): BJGPO.2022.0123. Published online 2023 Jan 25. doi: 10.3399/BJGPO.2022.0123

PMCID:: PMC10354331

Article PDF–960K

Select item 725970720.

Attitudes toward animals, and how species and purpose affect animal research justifiability, among undergraduate students and faculty

Eric P. Sandgren, Robert Streiffer, Jennifer Dykema, Nadia Assad, Jackson Moberg

PLoS One. 2020; 15(5): e0233204. Published online 2020 May 29. doi: 10.1371/journal.pone.0233204

PMCID:: PMC7259707

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PMC Images search for translatability【计】

Fig. 1

Schematic representation of a proposed strategy for evaluation of Model Translatability and Transferability of health models.

Translatability and transferability of in silico models: Context of use switching to predict the effects of environmental chemicals on the immune system

Comput Struct Biotechnol J. 2022;20:1764-1777.
FIGURE 3

Multiple preclinical neuropathic pain assessment endpoints in development to improve translatability of preclinical to clinical research. *Primary endpoint, RCT (randomised clinical trial), EEG (electroencephalogram), QoL (quality of life).

Preclinical Neuropathic Pain Assessment; the Importance of Translatability and Bidirectional Research

Front Pharmacol. 2020;11:614990.
Figure 3. Translatability of National Institutes of Health–Funded Biomedical Research Applying Artificial Intelligence, by Category of Artificial Intelligence Applications

The areas of the bubbles reflect the relative amount of National Institutes of Health research funding allocated to each category of artificial intelligence applications.

Translatability Analysis of National Institutes of Health–Funded Biomedical Research That Applies Artificial Intelligence

JAMA Netw Open. 2022 Jan;5(1):e2144742.
Fig. 3

Relative severity and translatability of all instruments compared to Sampson5 for food and drug challenges. The relative severity is presented as 10,000-AUC for each CDF curve, whereas translatability represent the percentage of challenges in Sampson5 to be translated. *Sampson5 unmodified

Assessing severity of anaphylaxis: a data-driven comparison of 23 instruments

Clin Transl Allergy. 2018;8:29.