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Select item 81182051.

Evaluation of spermicidal activity of saponosides from Saponaria officinalis/Caryophyllaceae, Glycyrrhizia glabra/Fabaceae and Herniaria glabra/Caryophyllaceae

Mohamed Réda Sefrioui, Ibrahim Sbai El Othmani, Halima Filali, Sanae Derfoufi, Soufiane Derraji, Adnane Benmoussa, Amal Ait Haj Said

Med Pharm Rep. 2021 Apr; 94(2): 239–247. Published online 2021 Apr 29. doi: 10.15386/mpr-1879

PMCID:: PMC8118205

Abstract Article PDF–467K

Select item 37282322.

Spermicidal and anti-Trichomonas vaginalis activity of Brazilian Sapindus saponaria

Edilson Damke, Joyce K Tsuzuki, Francieli Chassot, Diógenes AG Cortez, Izabel CP Ferreira, Cristiane SS Mesquita, Vânia RS da-Silva, Terezinha IE Svidzinski, Márcia EL Consolaro

BMC Complement Altern Med. 2013; 13: 196. Published online 2013 Jul 28. doi: 10.1186/1472-6882-13-196

PMCID:: PMC3728232

Abstract Article PDF–1.8M

Select item 41713793.

Spermicidal and Contraceptive Potential of Desgalactotigonin: A Prospective Alternative of Nonoxynol-9

Debanjana Chakraborty, Arindam Maity, Tarun Jha, Nirup Bikash Mondal

PLoS One. 2014; 9(9): e107164. Published online 2014 Sep 22. doi: 10.1371/journal.pone.0107164

PMCID:: PMC4171379

Abstract Article PDF–1.9M

Select item 38411154.

Evaluation of the Spermicidal and Contraceptive Activity of Platycodin D, a Saponin from Platycodon grandiflorum

Zongliang Lu, Leiguang Wang, Rui Zhou, Yi Qiu, Liuna Yang, Chanyu Zhang, Min Cai, Mantian Mi, Hongxia Xu

PLoS One. 2013; 8(11): e82068. Published online 2013 Nov 26. doi: 10.1371/journal.pone.0082068

PMCID:: PMC3841115

Abstract Article PDF–2.3M

Select item 97247805.

17BIPHE2, an engineered cathelicidin antimicrobial peptide with low susceptibility to proteases, is an effective spermicide and microbicide against Neisseria gonorrhoeae

Seung Gee Lee, Wongsakorn Kiattiburut, Thitiporn Khongkha, Stephanie C Burke Schinkel, Yvonne Lunn, Aaron P Decker, Avid Mohammadi, Ana Vera-Cruz, Avika Misra, Jonathan B Angel, Deborah J Anderson, Mark Baker, Rupert Kaul, Guangshun Wang, Nongnuj Tanphaichitr

Hum Reprod. 2022 Nov; 37(11): 2503–2517. Published online 2022 Sep 2. doi: 10.1093/humrep/deac188

PMCID:: PMC9724780

Abstract Article PDF–1.2M

Select item 62383676.

Antimicrobial peptide LL-37 and its truncated forms, GI-20 and GF-17, exert spermicidal effects and microbicidal activity against Neisseria gonorrhoeae

Wongsakorn Kiattiburut, Ruina Zhi, Seung Gee Lee, Alexander C Foo, Duane R Hickling, Jeffrey W Keillor, Natalie K Goto, Weihua Li, Wayne Conlan, Jonathan B Angel, Guangshun Wang, Nongnuj Tanphaichitr

Hum Reprod. 2018 Dec; 33(12): 2175–2183. Published online 2018 Oct 24. doi: 10.1093/humrep/dey315

PMCID:: PMC6238367

Abstract Article PDF–564K

Select item 72861787.

Tideglusib, a prospective alternative to nonoxynol-9 contraceptive

Zhiting Chen, Niyan Shu, Yuzhu Wang, Yiting Yang, Zhiyu Shao, Fang Tian, Minjie Xia, Zhikai Wang, Xin Wang, Xing Feng, Xianliang Huang, Weihua Li, Heguo Yu, Hua Diao

Contracept X. 2019; 1: 100007. Published online 2019 Apr 25. doi: 10.1016/j.conx.2019.100007

PMCID:: PMC7286178

Abstract Article PDF–1.4M

Select item 77241548.

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

Mengjie Xie, Junlang Li, Sichen Zhang, Dashuai Zhu, Xuan Mei, Zhenzhen Wang, Xiao Cheng, Zhenhua Li, Shaowei Wang, Ke Cheng

Bioact Mater. 2021 Jun; 6(6): 1777–1788. Published online 2020 Dec 3. doi: 10.1016/j.bioactmat.2020.11.031

PMCID:: PMC7724154

Abstract Article PDF–12M

Select item 27506239.

Coprecipitation of nonoxynol-9 with polyvinylpyrrolidone to decrease vaginal irritation potential while maintaining spermicidal potency

Philip T. Fowler, Gustavo F. Doncel, Paul M. Bummer, George A. Digenis

AAPS PharmSciTech. 2003 Sep; 4(3): 10–17. Published online 2003 Jun 6. doi: 10.1208/pt040330

PMCID:: PMC2750623

Summary PDF–291K

Select item 903710210.

Chemistry of trisindolines: natural occurrence, synthesis and bioactivity

First Ambar Wati, Mardi Santoso, Ziad Moussa, Sri Fatmawati, Arif Fadlan, Zaher M. A. Judeh

RSC Adv. 2021 Jul 19; 11(41): 25381–25421. Published online 2021 Jul 21. doi: 10.1039/d1ra03091d

PMCID:: PMC9037102

Abstract Article PDF–5.1M

Select item 316535911.

Novel Trichomonacidal Spermicides

Ashish Jain, Nand Lal, Lokesh Kumar, Vikas Verma, Rajeev Kumar, Lalit Kumar, Vishal Singh, Raghav K. Mishra, Amit Sarswat, S. K. Jain, J. P. Maikhuri, V. L. Sharma, Gopal Gupta

Antimicrob Agents Chemother. 2011 Sep; 55(9): 4343–4351. doi: 10.1128/AAC.00199-11

PMCID:: PMC3165359

Abstract Article PDF–370K

Select item 256555312.

Spermicidal Activity of the Safe Natural Antimicrobial Peptide Subtilosin

Katia E. Sutyak, Robert A. Anderson, Sara E. Dover, Kenneth A. Feathergill, Alla A. Aroutcheva, Sebastian Faro, Michael L. Chikindas

Infect Dis Obstet Gynecol. 2008; 2008: 540758. Published online 2008 Oct 9. doi: 10.1155/2008/540758

PMCID:: PMC2565553

Abstract Article PDF–548K

Select item 481237713.

Potential Use of Antimicrobial Peptides as Vaginal Spermicides/Microbicides

Nongnuj Tanphaichitr, Nopparat Srakaew, Rhea Alonzi, Wongsakorn Kiattiburut, Kessiri Kongmanas, Ruina Zhi, Weihua Li, Mark Baker, Guanshun Wang, Duane Hickling

Pharmaceuticals (Basel) 2016 Mar; 9(1): 13. Published online 2016 Mar 11. doi: 10.3390/ph9010013

PMCID:: PMC4812377

Abstract Article PDF–3.3M

Select item 369495914.

Designed Chemical Intervention with Thiols for Prophylactic Contraception

Monika Sharma, Lokesh Kumar, Ashish Jain, Vikas Verma, Vikas Sharma, Bhavana Kushwaha, Nand Lal, Lalit Kumar, Tara Rawat, Anil K. Dwivedi, Jagdamba P. Maikhuri, Vishnu L. Sharma, Gopal Gupta

PLoS One. 2013; 8(6): e67365. Published online 2013 Jun 27. doi: 10.1371/journal.pone.0067365

PMCID:: PMC3694959

Abstract Article PDF–916K

Select item 333209215.

A randomized trial of the contraceptive efficacy, acceptability, and safety of C31G and nonoxynol-9 spermicidal gels

Anne E. Burke, Kurt Barnhart, Jeffrey T. Jensen, Mitchell D. Creinin, Terri L. Walsh, Livia S. Wan, Carolyn Westhoff, Michael Thomas, David Archer, Hongsheng Wu, James Liu, William Schlaff, Bruce R Carr, Diana Blithe

Obstet Gynecol. Author manuscript; available in PMC 2012 Apr 22.

Published in final edited form as: Obstet Gynecol. 2010 Dec; 116(6): 1265–1273. doi: 10.1097/AOG.0b013e3181fc3b1a

PMCID:: PMC3332092

Abstract Article PDF–988K

Select item 645280916.

G1-S4 or G2-S16 carbosilane dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity

Rafael Ceña-Diez, Alba Martin-Moreno, F Javier de la Mata, Rafael Gómez-Ramirez, Eduardo Muñoz, Manuel Ardoy, Ma Ángeles Muñoz-Fernández

Int J Nanomedicine. 2019; 14: 2371–2381. Published online 2019 Apr 2. doi: 10.2147/IJN.S188495

PMCID:: PMC6452809

Abstract Article PDF–779K

Select item 333641517.

SPERMICIDAL ACTIVITY IN VITRO OF BARK EXTRACT OF AZADIRACHTA INDICA IN RATS

Vinita Bhargava, A.O. Prakash

Anc Sci Life. 2000 Jul-Dec; 20(1-2): 77–81.

PMCID:: PMC3336415

Summary PDF–214K

Select item 939369518.

Phytochemical Constituents and In vitro Pharmacological Response of Cnidium monnieri; A Natural Ancient Medicinal Herb

Naveed Munir, Zahed Mehmood, Muhammad Shahid, Samina Aslam, Mazhar Abbas, Huma Mehboob, Samiah H. Al-Mijallia, Muhammad Jahangeer, Qurrat ul Ain Badar

Dose Response. 2022 Jul-Sep; 20(3): 15593258221115543. Published online 2022 Aug 17. doi: 10.1177/15593258221115543

PMCID:: PMC9393695

Abstract Article PDF–1.3M

Select item 822547819.

The amelioration of nicotine-induced reproductive impairment in male mouse by Sambucus ebulus L. fruit extract

Fahimeh Mohammadghasemi, Korosh Khanaki, Hamid Moravati, Masoumeh Faghani

Anat Cell Biol. 2021 Jun 30; 54(2): 232–240. Published online 2021 Jun 30. doi: 10.5115/acb.20.161

PMCID:: PMC8225478

Abstract Article PDF–4.3M

Select item 934747020.

Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation

Mahmoud H. Teaima, Moaz A. Eltabeeb, Mohamed A. El-Nabarawi, Menna M. Abdellatif

Drug Deliv. 2022; 29(1): 2549–2560. Published online 2022 Jul 31. doi: 10.1080/10717544.2022.2100514

PMCID:: PMC9347470

Abstract Article PDF–1.9M

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Figure 2

Effects of water-ethanol (WE) and butanolic (BE) extracts, and individual saponins (SP) of Sapindus saponaria on sperm motility in human semen. Mean ± SEM of percentage of viable spermatozoa (mobile) in different concentrations of WE, BE and SP, in three independent experiments. Nonoxynol-9 (N-9; 2%- 20 mg/g) was used as positive control or spermicidal solution. +p < 0.05, *p < 0.001.

Spermicidal and anti-Trichomonas vaginalis activity of Brazilian Sapindus saponaria

BMC Complement Altern Med. 2013;13:196-196.
Fig. 2

In vitro evaluation of the spermicidal and cytotoxic effects of the TGN gel. A. Representative brightfield image of the morphological observation of sperm. Scale bar, 100 μm. B. Measurement of spermicidal efficiency of the contraceptive gel containing different concentrations of gossypol acetate. C. Measurement of cytotoxicity of the TGN contraceptive gel on VK2/E6E7 cells. D. Quantification of CC50 level of the TGN contraceptive gel for cytotoxicity. E. Representative live (green)/dead (red) staining images of the cells cultured with gossypol acetate at different concentrations. White arrows indicate dead cells (in red). Scale bar, 100 μm.

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

Bioact Mater. 2021 Jun;6(6):1777-1788.
Fig. 2.

Inhibition of free thiols on human sperm by compound 2 (pyrrolidinium pyrrolidine-1-carbodithioate) at its spermicidal MEC (153 μM). The bars represent means ± the SE of three independent experiments using sperm from three different donors. Significant differences from the control (0.15% DMSO) are indicated as follows: ***, P < 0.001.

Novel Trichomonacidal Spermicides

Antimicrob Agents Chemother. 2011 Sep;55(9):4343-4351.
Figure 3The in vitro spermicidal and anti-trichomonal activities of pyrrolidinium pyrrolidine-1-carbodithioate (PPC) and its derivatives (BPC, IPC & HPC) with the active thiol blocked by alkylation.

(Mean ± SE of three independent experiments; MEC = minimum effective concentration; MIC = minimum inhibitory concentration).

Designed Chemical Intervention with Thiols for Prophylactic Contraception

PLoS One. 2013;8(6):e67365.