semicarbazone【有化】 - PMC

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Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site

Rati K. P. Tripathi, Vishnu M. Sasi, Sukesh K. Gupta, Sairam Krishnamurthy, Senthil R. Ayyannan

J Enzyme Inhib Med Chem. 2018; 33(1): 37–57. Published online 2017 Nov 3. doi: 10.1080/14756366.2017.1389920

PMCID:: PMC6009888

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Syntheses of Nickel (II) Complexes from Novel Semicarbazone Ligands with Chloroformylarylhydrazine, Benzimidazole and Salicylaldehyde Moieties

Mei-Hsiu Shih, Yu-Yuan Xu, Yu-Sheng Yang, Tzu-Ting Lin

Molecules. 2015 Mar; 20(3): 5184–5201. Published online 2015 Mar 20. doi: 10.3390/molecules20035184

PMCID:: PMC6272245

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Synthesis and Spectroscopic Identification of Certain Imidazole-Semicarbazone Conjugates Bearing Benzodioxole Moieties: New Antifungal Agents

Reem I. Al-Wabli, Alwah R. Al-Ghamdi, Hazem A. Ghabbour, Mohamed H. Al-Agamy, Mohamed I. Attia

Molecules. 2019 Jan; 24(1): 200. Published online 2019 Jan 7. doi: 10.3390/molecules24010200

PMCID:: PMC6337076

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Microwave-assisted synthesis, anticonvulsant activity and quantum mechanical modelling of N-(4-bromo-3-methylphenyl) semicarbazones

Mehta Shalini, Perumal Yogeeswari, Dharmarajan Sriram, Sridharan Induja

J Zhejiang Univ Sci B. 2007 Jan; 8(1): 45–55. Published online 2006 Dec 18. doi: 10.1631/jzus.2007.B0045

PMCID:: PMC1764922

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Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses

Valeria Francesconi, Elena Cichero, Silvia Schenone, Lieve Naesens, Michele Tonelli

Molecules. 2020 Apr; 25(7): 1487. Published online 2020 Mar 25. doi: 10.3390/molecules25071487

PMCID:: PMC7180491

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Interaction with Blood Proteins of a Ruthenium(II) Nitrofuryl Semicarbazone Complex: Effect on the Antitumoral Activity

Bruno Demoro, Andreia Bento-Oliveira, Fernanda Marques, João Costa Pessoa, Lucía Otero, Dinorah Gambino, Rodrigo F. M. de Almeida, Ana Isabel Tomaz

Molecules. 2019 Aug; 24(16): 2861. Published online 2019 Aug 7. doi: 10.3390/molecules24162861

PMCID:: PMC6719144

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Identification of Semicarbazones, Thiosemicarbazones and Triazine Nitriles as Inhibitors of Leishmania mexicana Cysteine Protease CPB

Jörg Schröder, Sandra Noack, Richard J. Marhöfer, Jeremy C. Mottram, Graham H. Coombs, Paul M. Selzer

PLoS One. 2013; 8(10): e77460. Published online 2013 Oct 16. doi: 10.1371/journal.pone.0077460

PMCID:: PMC3797739

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Hepatoprotective effect of acetone semicarbazone on Ehrlich ascites carcinoma induced carcinogenesis in experimental mice

Farhadul Islam, Shaikh Mohummad Mohsin Ali, Jahan Ara Khanam

Asian Pac J Trop Biomed. 2013 Feb; 3(2): 105–110. doi: 10.1016/S2221-1691(13)60033-7

PMCID:: PMC3627169

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Aminopeptidase N Inhibitors as Pointers for Overcoming Antitumor Treatment Resistance

Oldřich Farsa, Veronika Ballayová, Radka Žáčková, Peter Kollar, Tereza Kauerová, Peter Zubáč

Int J Mol Sci. 2022 Sep; 23(17): 9813. Published online 2022 Aug 29. doi: 10.3390/ijms23179813

PMCID:: PMC9456425

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Design and Synthesis of Novel Betulin Derivatives Containing Thio-/Semicarbazone Moieties as Apoptotic Inducers through Mitochindria-Related Pathways

Jiafeng Wang, Jiale Wu, Yinglong Han, Jie Zhang, Yu Lin, Haijun Wang, Jing Wang, Jicheng Liu, Ming Bu

Molecules. 2021 Nov; 26(21): 6356. Published online 2021 Oct 21. doi: 10.3390/molecules26216356

PMCID:: PMC8587101

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Novel Steroidal 5α,8α-Endoperoxide Derivatives with Semicarbazone/Thiosemicarbazone Side-chain as Apoptotic Inducers through an Intrinsic Apoptosis Pathway: Design, Synthesis and Biological Studies

Liwei Ma, Haijun Wang, Jing Wang, Lei Liu, Song Zhang, Ming Bu

Molecules. 2020 Mar; 25(5): 1209. Published online 2020 Mar 7. doi: 10.3390/molecules25051209

PMCID:: PMC7179397

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The antimicrobial activity of lapachol and its thiosemicarbazone and semicarbazone derivatives

Marina Azevêdo Souza, Susana Johann, Luciana Alves Rodrigues dos Santos Lima, Fernanda Fraga Campos, Isolda Castro Mendes, Heloisa Beraldo, Elaine Maria de Souza-Fagundes, Patrícia Silva Cisalpino, Carlos Augusto Rosa, Tânia Maria de Almeida Alves, Nívea Pereira de Sá, Carlos Leomar Zani

Mem Inst Oswaldo Cruz. 2013 May; 108(3): 342–351. doi: 10.1590/S0074-02762013000300013

PMCID:: PMC4005582

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Chalcones, semicarbazones and pyrazolines as inhibitors of cathepsins B, H and L

Neera Raghav, Ravinder Kaur

Int J Biol Macromol. 2015 Sep; 80: 710–724. Published online 2015 Jul 18. doi: 10.1016/j.ijbiomac.2015.07.029

PMCID:: PMC7124378

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Downregulation of oncogenic RAS and c-Myc expression in MOLT-4 leukaemia cells by a salicylaldehyde semicarbazone copper(II) complex

Yan-Yih Goh, Yaw-Kai Yan, Nguan Soon Tan, Su-Ann Goh, Shang Li, You-Chuan Teoh, Peter P. F. Lee

Sci Rep. 2016; 6: 36868. Published online 2016 Nov 14. doi: 10.1038/srep36868

PMCID:: PMC5107956

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Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

Eugene J. Gillespie, Chi-Lee C. Ho, Kavitha Balaji, Daniel L. Clemens, Gang Deng, Yao E. Wang, Heidi J. Elsaesser, Batcha Tamilselvam, Amandeep Gargi, Shandee D. Dixon, Bryan France, Brian T. Chamberlain, Steven R. Blanke, Genhong Cheng, Juan Carlos de la Torre, David G. Brooks, Michael E. Jung, John Colicelli, Robert Damoiseaux, Kenneth A. Bradley

Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50): E4904–E4912. Published online 2013 Nov 4. doi: 10.1073/pnas.1302334110

PMCID:: PMC3864319

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Characterization of sphingosine-1-phosphate lyase activity by ESI-LC/MS/MS quantitation of (2E)-hexadecenal

Evgeny V. Berdyshev, Jonathan Goya, Irina Gorshkova, Glenn D. Prestwich, Hoe-Sup Byun, Robert Bittman, Viswanathan Natarajan

Anal Biochem. Author manuscript; available in PMC 2012 Jan 1.

Published in final edited form as: Anal Biochem. 2011 Jan 1; 408(1): 12–18. Published online 2010 Sep 15. doi: 10.1016/j.ab.2010.08.026

PMCID:: PMC2964418

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Select item 375264717.

Molecular Modeling Optimization of Anticoagulant Pyridine Derivatives

Jose A. Hernandez Prada, Sandra L. Madden, David A. Ostrov, Maria A. Hernandez

J Mol Graph Model. Author manuscript; available in PMC 2013 Aug 26.

Published in final edited form as: J Mol Graph Model. 2008 Jun; 26(8): 1365–1369. Published online 2008 Feb 7. doi: 10.1016/j.jmgm.2008.01.006

PMCID:: PMC3752647

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Select item 941504118.

Facile Conversion of the Quinone-Semicarbazone Chromophore of Naftazone into a Fluorescent Quinol-Semicarbazide: Kinetic Study and Analysis of Naftazone in Pharmaceuticals and Human Serum

Mohammed Gamal, Hazim M. Ali, Rania El-Shaheny, Ibrahim A. Naguib, Izzeddin Alsalahat, Mahmoud El-Maghrabey

Sensors (Basel) 2022 Aug; 22(16): 6205. Published online 2022 Aug 18. doi: 10.3390/s22166205

PMCID:: PMC9415041

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Select item 157606119.

V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels

Victor I Ilyin, Dianne D Hodges, Edward R Whittemore, Richard B Carter, Sui Xiong Cai, Richard M Woodward

Br J Pharmacol. 2005 Mar; 144(6): 801–812. Published online 2005 Mar 21. doi: 10.1038/sj.bjp.0706058

PMCID:: PMC1576061

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In vivo anticancer activity of vanillin semicarbazone

Shaikh M Mohsin Ali, M Abul Kalam Azad, Mele Jesmin, Shamim Ahsan, M Mijanur Rahman, Jahan Ara Khanam, M Nazrul Islam, Sha M Shahan Shahriar

Asian Pac J Trop Biomed. 2012 Jun; 2(6): 438–442. doi: 10.1016/S2221-1691(12)60072-0

PMCID:: PMC3609319

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Fig. 1synthesis of lapachol thiosemicarbazone and semicarbazone and structures of lapachol (A), lapachol derivatives thiosemicarbazone (B) and semicarbazone (C).

The antimicrobial activity of lapachol and its thiosemicarbazone and semicarbazone derivatives

Mem Inst Oswaldo Cruz. 2013 May;108(3):342-351.
Figure 21

Positive product ion mass spectra of fatty aldehyde semicarbazone derivatives. (A) (2E)-Hexadecenal semicarbazone product ions. (B) cis-11-Hexadecenal semicarbazone product ions. (C) Hexadecanal semicarbazone product ions. (D) Proposed pathways for product ion formation during (2E)-hexadecenal semicarbazone CID. cps, counts per second (reproduced from [[]] with permission from Elsevier).

MASS SPECTROMETRY OF FATTY ALDEHYDES

Biochim Biophys Acta. ;1811(11):680-693.
Figure 2

Positive product ion mass spectra of fatty aldehyde semicarbazone derivatives. (A) (2E)-Hexadecenal semicarbazone product ions. (B) cis-11-Hexadecenal semicarbazone product ions. (C) Hexadecanal semicarbazone product ions. (D) Proposed pathways for product ion formation during (2E)-hexadecenal semicarbazone collision-induced decomposition. Refer to text for the parameters of declustering, collision-induced decomposition, and collision cell exit potentials.

Characterization of sphingosine-1-phosphate lyase activity by ESI-LC/MS/MS quantitation of (2E)-hexadecenal

Anal Biochem. ;408(1):12-18.
Figure 3

The NMR spectrum of semicarbazone 13a.

Syntheses of Nickel (II) Complexes from Novel Semicarbazone Ligands with Chloroformylarylhydrazine, Benzimidazole and Salicylaldehyde Moieties

Molecules. 2015 Mar;20(3):5184-5201.