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Select item 31679051.

Polyethylenimine-cyclodextrin-tegafur conjugate shows anti-cancer activity and a potential for gene delivery

Qi-da Hu, Hui Fan, Wei-jian Lou, Qing-qing Wang, Gu-ping Tang

J Zhejiang Univ Sci B. 2011 Sep; 12(9): 720–729. doi: 10.1631/jzus.B1000307

PMCID:: PMC3167905

Article PDF–642K

Select item 78622542.

Simultaneous quantification method for 5-FU, uracil, and tegafur using UPLC-MS/MS and clinical application in monitoring UFT/LV combination therapy after hepatectomy

Ken Shiraiwa, Yosuke Suzuki, Hiroki Uchida, Yukio Iwashita, Ryota Tanaka, Motoshi Iwao, Kazuhiro Tada, Teijiro Hirashita, Takashi Masuda, Yuichi Endo, Masafumi Inomata, Hiroki Itoh

Sci Rep. 2021; 11: 3132. Published online 2021 Feb 4. doi: 10.1038/s41598-021-82908-8

PMCID:: PMC7862254

Article PDF–1.1M

Select item 23600303.

Uracil/ftorafur/leucovorin combined with irinotecan (TEGAFIRI) or oxaliplatin (TEGAFOX) as first-line treatment for metastatic colorectal cancer patients: results of randomised phase II study

E Bajetta, M Di Bartolomeo, R Buzzoni, L Mariani, N Zilembo, E Ferrario, S Lo Vullo, E Aitini, L Isa, C Barone, S Jacobelli, E Recaldin, G Pinotti, A Iop

Br J Cancer. 2007 Feb 12; 96(3): 439–444. Published online 2007 Jan 23. doi: 10.1038/sj.bjc.6603493

PMCID:: PMC2360030

Article PDF–102K

Select item 66980014.

Monthly tegafur–uracil maintenance for increasing relapse-free survival in ypStage III rectal cancer patients after preoperative radiotherapy, radical resection, and 12 postoperative chemotherapy cycles: a retrospective study

Yi-Hung Kuo, Chia-Hsuan Lai, Cheng-Yi Huang, Chih-Jung Chen, Yun-Ching Huang, Wen-Shih Huang, Chih-Chien Chin

BMC Cancer. 2019; 19: 815. Published online 2019 Aug 17. doi: 10.1186/s12885-019-6019-0

PMCID:: PMC6698001

Article PDF–1.3M

Select item 3520065.

Comparison of the Actions of 5-Fluorouracil and Ftorafur in Escherichia coli

Priscilla P. Saunders, Lian-Yu Chao

Antimicrob Agents Chemother. 1977 Mar; 11(3): 451–454. doi: 10.1128/aac.11.3.451

PMCID:: PMC352006

Summary Page Browse PDF–412K

Select item 23610766.

‘A phase II study of oral uracil/ftorafur (UFT®) plus leucovorin combined with oxaliplatin (TEGAFOX) as first-line treatment in patients with metastatic colorectal cancer’

J Bennouna, H Perrier, B Paillot, F Priou, J H Jacob, M Hebbar, S Bordenave, J F Seitz, F Cvitkovic, E Dorval, K Malek, D Tonelli, J Y Douillard

Br J Cancer. 2006 Jan 16; 94(1): 69–73. Published online 2005 Dec 13. doi: 10.1038/sj.bjc.6602913

PMCID:: PMC2361076

Article PDF–111K

Select item 59188367.

Metabolism of Tegafur in Rat Liver Observed by in vivo ¹⁹F Magnetic Resonance Spectroscopy and Chromatography

Masafumi Harada, Hiromu Nishitani, Keiko Koga, Iwao Miura, Yukihiko Umeno

Jpn J Cancer Res. 1992 Apr; 83(4): 387–391. doi: 10.1111/j.1349-7006.1992.tb00119.x

PMCID:: PMC5918836

Article PDF–286K

Select item 19712978.

Oral tegafur in the treatment of gastrointestinal tract cancers: a phase II study.

S. Palmeri, V. Gebbia, A. Russo, M. G. Armata, N. Gebbia, L. Rausa

Br J Cancer. 1990 Mar; 61(3): 475–478. doi: 10.1038/bjc.1990.105

PMCID:: PMC1971297

Summary Page Browse PDF–741K

Select item 59267409.

Expression of CYP2A6 in Tumor Cells Augments Cellular Sensitivity to Tegafur

Norie Murayama, Kimie Sai, Yukiko Nakajima, Naoko Kaniwa, Shogo Ozawa, Yasuo Ohno, Jun‐ichi Sawada

Jpn J Cancer Res. 2001 May; 92(5): 524–528. doi: 10.1111/j.1349-7006.2001.tb01125.x

PMCID:: PMC5926740

Article PDF–128K

Select item 648312210.

Oral versus intravenous fluoropyrimidines for colorectal cancer

Fiona Chionh, David Lau, Yvonne Yeung, Timothy Price, Niall Tebbutt, Cochrane Colorectal Cancer Group

Cochrane Database Syst Rev. 2017; 2017(7): CD008398. Published online 2017 Jul 28. doi: 10.1002/14651858.CD008398.pub2

PMCID:: PMC6483122

Article PDF–2.2M

Select item 592608911.

Therapeutic Effect of 1 M Tegafur‐0.4 M 5‐Chloro‐2,4‐dihydroxypyridine‐1 M Potassium Oxonate (S‐1) on Liver Metastasis of Xenotransplanted Human Colon Carcinoma

Hiroyuki Konno, Tatsuo Tanaka, Megumi Baba, Toshikazu Kanai, Keigo Matsumoto, Kinji Kamiya, Satoshi Nakamura

Jpn J Cancer Res. 1999 Apr; 90(4): 448–453. doi: 10.1111/j.1349-7006.1999.tb00768.x

PMCID:: PMC5926089

Article PDF–3.2M

Select item 771868412.

A single-arm, phase 2 study of adjuvant chemotherapy with oral tegafur-uracil for pathologically lymphovascular invasion positive stage IA non-small cell lung cancer: LOGIK0602 study

Tomoshi Tsuchiya, Ryotaro Kamohara, Masashi Muraoka, Takeshi Nagayasu, Sho Saeki, Mitsuhiro Takenoyama, Makoto Suzuki, Kazuo Inada, Shoji Tokunaga, Tomayoshi Hayashi, Shogo Urabe, Takaomi Koga, Shinji Akamine, Kenji Sugio

BMC Cancer. 2020; 20: 1192. Published online 2020 Dec 4. doi: 10.1186/s12885-020-07691-7

PMCID:: PMC7718684

Article PDF–504K

Select item 545233413.

Efficacy and short-term outcomes of preoperative chemoradiotherapy with intermittent oral tegafur-uracil plus leucovorin in Japanese rectal cancer patients: a single center experience retrospective analysis

Ryosuke Nakagawa, Yuji Inoue, Takeshi Ohki, Yuka Kaneko, Fumi Maeda, Masakazu Yamamoto

World J Surg Oncol. 2017; 15: 112. Published online 2017 May 31. doi: 10.1186/s12957-017-1177-5

Correction in:: World J Surg Oncol. 2017; 15: 171.

PMCID:: PMC5452334

Article PDF–922K

Select item 551495314.

Maintenance treatment of Uracil and Tegafur (UFT) in responders following first-line fluorouracil-based chemotherapy in metastatic gastric cancer: a randomized phase II study

Wenhua Li, Xiaoying Zhao, Huijie Wang, Xin Liu, Xinmin Zhao, Mingzhu Huang, Lixin Qiu, Wen Zhang, Zhiyu Chen, Weijian Guo, Jin Li, Xiaodong Zhu

Oncotarget. 2017 Jun 6; 8(23): 37826–37834. Published online 2016 Dec 12. doi: 10.18632/oncotarget.13922

PMCID:: PMC5514953

Article PDF–809K

Select item 791912515.

Tegafur‐uracil‐induced pericardial effusion during adjuvant chemotherapy for resected lung adenocarcinoma: A case report

Nobutaka Kawamoto, Riki Okita, Masataro Hayashi, Masanori Okada, Hidetoshi Inokawa

Thorac Cancer. 2021 Mar; 12(5): 707–710. Published online 2021 Jan 18. doi: 10.1111/1759-7714.13840

PMCID:: PMC7919125

Article PDF–3.6M

Select item 382420016.

Evidence produced in Japan: tegafur-based preparations for postoperative chemotherapy in breast cancer

Toru Watanabe

Breast Cancer. 2013; 20(4): 302–309. Published online 2013 Mar 1. doi: 10.1007/s12282-013-0451-9

PMCID:: PMC3824200

Article PDF–232K

Select item 615171317.

Effect of Sipjeondaebo-Tang on the Pharmacokinetics of S-1, an Anticancer Agent, in Rats Evaluated by Population Pharmacokinetic Modeling

Tae Hwan Kim, Soyoung Shin, Jeong Cheol Shin, Jürgen B. Bulitta, Kwon-Yeon Weon, Sun Dong Yoo, Gi-Young Park, Seok Won Jeong, Dong Rak Kwon, Byung Sun Min, Mi Hee Woo, Beom Soo Shin

Molecules. 2017 Sep; 22(9): 1488. Published online 2017 Sep 7. doi: 10.3390/molecules22091488

PMCID:: PMC6151713

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Select item 673265718.

Pharmacokinetic and bioequivalence study between two formulations of S-1 in Korean gastric cancer patients

Hae Won Lee, Sook Jin Seong, Woo Youl Kang, Boram Ohk, Mi-Ri Gwon, Bo Kyung Kim, Seungil Cho, Kyunghee Cho, Yong Kyung Sung, Young-Ran Yoon, Jong Gwang Kim

Drug Des Devel Ther. 2019; 13: 3127–3136. Published online 2019 Sep 3. doi: 10.2147/DDDT.S219822

PMCID:: PMC6732657

Article PDF–808K

Select item 556929819.

Tegafur-uracil-induced rapid development of advanced hepatic fibrosis

Shuya Honda, Koji Sawada, Takumu Hasebe, Shunsuke Nakajima, Mikihiro Fujiya, Toshikatsu Okumura

World J Gastroenterol. 2017 Aug 21; 23(31): 5823–5828. Published online 2017 Aug 21. doi: 10.3748/wjg.v23.i31.5823

PMCID:: PMC5569298

Article PDF–1.3M

Select item 540550220.

Maintenance tegafur-uracil versus observation following an adjuvant oxaliplatin-based regimen in patients with stage III colon cancer after radical resection: study protocol for a randomized controlled trial

Yung-Sung Yeh, Hsiang-Lin Tsai, Ching-Wen Huang, Po-Li Wei, Yung-Chuan Sung, Hsiu-Chih Tang, Jaw-Yuan Wang

Trials. 2017; 18: 191. Published online 2017 Apr 26. doi: 10.1186/s13063-017-1904-9

PMCID:: PMC5405502

Article PDF–975K

Did you mean: torafur (1 items)

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PMC Images search for ftorafur【药】

Figure 3

The structures of 5-FU, ethynyluracil, ftorafur and S-1.

A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer

Br J Clin Pharmacol. 1999 Sep;48(3):265-277.
Figure 3

Neutrophil extracellular trap in the blood of a patient with cervical cancer after radiation therapy with ftorafur (Hematoxylin-eosin staining, 1400 x magnification)

Influence of Combined Therapy on Generation of Neutrophil Extracellular Traps in Patients with Cervical Cancer

Open Access Maced J Med Sci. 2018 Nov 25;6(11):2097-2100.
Figure 2

The activation and metabolic pathway of a) S-1 and b) UFT. CDHP, chlorodihydropyrimidine; FT, ftorafur; Oxo, oxonic acid; PPRT, pyrimidine phosphoribosyl transferase; P-450, cytochrome P450; U, uracil. — — → inhibition, ⇝ activation.

A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer

Br J Clin Pharmacol. 1999 Sep;48(3):265-277.
Figure 6.

Calibration curve families. Cyclic voltammetric measurements, in PBS, obtained for all drugs in their pharmacological range and etoposide at fixed concentrations (0–25–50–75–100 μM). Cytochrome P4503A4 was used for ifosfamide (A), cytochrome P4503A4 for cyclophosphamide (B), and cytochrome P4501A2 for ftorafur (C). Calibration curves for etoposide detection in its pharmacological range obtained with a CNT-electrode in presence of ifosfamide at fixed concentrations (0–40–80–120–160 μM) are illustrated in (D).

Electrochemical Detection of Anti-Breast-Cancer Agents in Human Serum by Cytochrome P450-Coated Carbon Nanotubes

Sensors (Basel). 2012;12(5):6520-6537.