destrin - PMC

Claus Cursiefen, Sakae Ikeda, Patsy M. Nishina, Richard S. Smith, Akihiro Ikeda, David Jackson, Jun-Song Mo, Lu Chen, M. Reza Dana, Bronislaw Pytowski, Friedrich E. Kruse, J. Wayne Streilein

Am J Pathol. 2005 May; 166(5): 1367–1377. doi: 10.1016/S0002-9440(10)62355-3

PMCID:: PMC1606392

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Abnormal epithelial homeostasis in the cornea of mice with a destrin deletion

W. Zhang, J. Zhao, L. Chen, M. M. Urbanowicz, T. Nagasaki

Mol Vis. 2008; 14: 1929–1939. Published online 2008 Oct 28.

PMCID:: PMC2573731

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Actin Depolymerizing Factors Cofilin1 and Destrin Are Required for Ureteric Bud Branching Morphogenesis

Satu Kuure, Cristina Cebrian, Quentin Machingo, Benson C. Lu, Xuan Chi, Deborah Hyink, Vivette D'Agati, Christine Gurniak, Walter Witke, Frank Costantini

PLoS Genet. 2010 Oct; 6(10): e1001176. Published online 2010 Oct 28. doi: 10.1371/journal.pgen.1001176

PMCID:: PMC2965756

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Differences in corneal phenotypes between destrin mutants are due to allelic difference and modified by genetic background

Sharolyn V. Kawakami-Schulz, Angela M. Verdoni, Shannon G. Sattler, Akihiro Ikeda, Sakae Ikeda

Mol Vis. 2012; 18: 606–616. Published online 2012 Mar 3.

PMCID:: PMC3298451

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Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea

Sharolyn V. Kawakami-Schulz, Angela M. Verdoni, Shannon G. Sattler, Erik Jessen, Winston W.-Y. Kao, Akihiro Ikeda, Sakae Ikeda

Physiol Genomics. 2014 Apr 15; 46(8): 277–289. Published online 2014 Feb 18. doi: 10.1152/physiolgenomics.00126.2013

PMCID:: PMC4035658

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The effect of destrin mutations on the gene expression profile in vivo

Angela M. Verdoni, Natsuyo Aoyama, Akihiro Ikeda, Sakae Ikeda

Physiol Genomics. Author manuscript; available in PMC 2009 Jun 12.

Published in final edited form as: Physiol Genomics. 2008 Jun 12; 34(1): 9–21. Published online 2008 Apr 1. doi: 10.1152/physiolgenomics.00285.2007

PMCID:: PMC2435404

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Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes

Dominique Talabot-Ayer, Loïc Mermoud, Julia Borowczyk, Justyna Drukala, Michal Wolnicki, Ali Modarressi, Wolf-Henning Boehncke, Nicolo Brembilla, Gaby Palmer

PLoS One. 2019; 14(11): e0225782. Published online 2019 Nov 26. doi: 10.1371/journal.pone.0225782

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Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity

Chen Luxenburg, Evan Heller, H. Amalia Pasolli, Sophia Chai, Maria Nikolova, Nicole Stokes, Elaine Fuchs

Nat Cell Biol. Author manuscript; available in PMC 2015 Aug 3.

Published in final edited form as: Nat Cell Biol. 2015 May; 17(5): 592–604. Published online 2015 Apr 27. doi: 10.1038/ncb3146

PMCID:: PMC4523270

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Actin cytoskeleton redox proteome oxidation by cadmium

Young-Mi Go, Michael Orr, Dean P. Jones

Am J Physiol Lung Cell Mol Physiol. 2013 Dec 1; 305(11): L831–L843. Published online 2013 Sep 27. doi: 10.1152/ajplung.00203.2013

PMCID:: PMC3882527

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F-actin and G-actin binding are uncoupled by mutation of conserved tyrosine residues in maize actin depolymerizing factor (ZmADF)

Chang-Jie Jiang, Alan G. Weeds, Safina Khan, Patrick J. Hussey

Proc Natl Acad Sci U S A. 1997 Sep 2; 94(18): 9973–9978. doi: 10.1073/pnas.94.18.9973

PMCID:: PMC23314

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Identification of Genes Expressed in the Migrating Primitive Myeloid Lineage of Xenopus laevis

Zachary N. Agricola, Amrita K. Jagpal, Andrew W. Allbee, Allison R. Prewitt, Emily T. Shifley, Scott A. Rankin, Aaron M. Zorn, Alan P. Kenny

Dev Dyn. Author manuscript; available in PMC 2017 Apr 11.

Published in final edited form as: Dev Dyn. 2016 Jan; 245(1): 47–55. Published online 2015 Nov 20. doi: 10.1002/dvdy.24314

PMCID:: PMC5387764

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Genetic modification of corneal neovascularization in Dstn^corn1 mice

Sharolyn V. Kawakami-Schulz, Shannon G. Sattler, Anna-Lisa Doebley, Akihiro Ikeda, Sakae Ikeda

Mamm Genome. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Mamm Genome. 2013 Oct; 24(0): 349–357. Published online 2013 Aug 9. doi: 10.1007/s00335-013-9468-9

PMCID:: PMC3802551

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Identification of functional pathways associated with the conditional ablation of serum response factor in Dstn^corn1 mice

Yanan Huo, Xin Xie, Bo Jiang

Mol Med Rep. 2017 Jan; 15(1): 139–145. Published online 2016 Dec 5. doi: 10.3892/mmr.2016.5984

PMCID:: PMC5355747

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KIAA1199 is a secreted molecule that enhances osteoblastic stem cell migration and recruitment

Li Chen, Kaikai Shi, Thomas Levin Andersen, Weimin Qiu, Moustapha Kassem

Cell Death Dis. 2019 Feb; 10(2): 126. Published online 2019 Feb 12. doi: 10.1038/s41419-018-1202-9

PMCID:: PMC6372631

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Defects in Actin Dynamics Lead to an Autoinflammatory Condition through the Upregulation of CXCL5

Angela M. Verdoni, Richard S. Smith, Akihiro Ikeda, Sakae Ikeda

PLoS One. 2008; 3(7): e2701. Published online 2008 Jul 16. doi: 10.1371/journal.pone.0002701

PMCID:: PMC2442876

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The Three Mouse Actin-depolymerizing Factor/Cofilins Evolved to Fulfill Cell-Type–specific Requirements for Actin Dynamics

Maria K. Vartiainen, Tuija Mustonen, Pieta K. Mattila, Pauli J. Ojala, Irma Thesleff, Juha Partanen, Pekka Lappalainen

Mol Biol Cell. 2002 Jan; 13(1): 183–194. doi: 10.1091/mbc.01-07-0331

PMCID:: PMC65081

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ADF/Cofilin: A Functional Node in Cell Biology

Barbara W. Bernstein, James R. Bamburg

Trends Cell Biol. Author manuscript; available in PMC 2011 Apr 1.

Published in final edited form as: Trends Cell Biol. 2010 Apr; 20(4): 187–195. Published online 2010 Feb 3. doi: 10.1016/j.tcb.2010.01.001

PMCID:: PMC2849908

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Solution structure and dynamics of ADF from Toxoplasma gondii

Rahul Yadav, Prem Prakash Pathak, Vaibhav Shukla, Anupam Jain, Shubhra Srivastava, Sarita Tripathi, S.V.S.R. Krishna Pulavarti, Simren Mehta, L. David Sibley, Ashish Arora

J Struct Biol. Author manuscript; available in PMC 2013 Jul 7.

Published in final edited form as: J Struct Biol. 2011 Oct; 176(1): 97–111. Published online 2011 Jul 26. doi: 10.1016/j.jsb.2011.07.011

PMCID:: PMC3703439

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PMC Images search for destrin

Figure 5DADS inhibited the expression of destrin (ADF) and p-cofilin1 in colon cancer cells.

(a) RT-PCR was used to detect the effect of DADS on the expression of destrin andcofilin1mRNA in colon cancer cells with or without transfection. (b) Western blot was used to detect the effect of DADS on the protein expression of destrin (normalized to GAPDH), cofilin1, and p-cofilin1 (normalized to cofilin1) in colon cancer cells with or without transfection.*P < 0.05 vs SW480 or vector group; ^#P < 0.05 vs SW480, vector, DADS + vector or DADS + SW480, and DADS + LIMK1/SW480 groups.

Downregulation of LIMK1–ADF/cofilin by DADS inhibits the migration and invasion of colon cancer

Sci Rep. 2017;7:45624.
Figure 1High expression of LIMK1 and destrin in colon cancer tissues.

Representative images of LIMK1 and destrin, as detected by immunohistochemical analysis in normal mucosa and tumor samples (magnification x400). Brown denotes a positive signal.

Downregulation of LIMK1–ADF/cofilin by DADS inhibits the migration and invasion of colon cancer

Sci Rep. 2017;7:45624.
Fig. 8.

Low-dose Cd stimulated F-actin formation and nuclear localization of destrin. Mouse LF treated with nothing or Cd (0.5, 1.0 μM, 18 h) were examined for filamentous actin (F-actin, green) and destrin by fluorescence microscopy (×60), and representative images are shown. Cd-induced destrin localization in cell nuclei is shown in the merged image with nucleus staining. Blue, Hoechst-labeled nuclei; orange, Cy3-conjugated destrin; green, BODIPY FL phallacidin-labeled F-actin.

Actin cytoskeleton redox proteome oxidation by cadmium

Am J Physiol Lung Cell Mol Physiol. 2013 Dec 1;305(11):L831-L843.
Figure 2Expression of LIMK1 and destrin was significantly correlated with the survival of patients with colon cancer.

Kaplan−Meier estimated OS for patients with colon cancer according to the expression of LIMK1 and destrin. The OS curves for patients with low or high expression of LIMK1 are shown. The increased expression of LIMK1 and destrin was correlated with poor OS. P values were obtained using the log-rank test. N, Number of cases; events, thenumber of patients who had arecurrent tumor or died during the follow-up period.

Downregulation of LIMK1–ADF/cofilin by DADS inhibits the migration and invasion of colon cancer

Sci Rep. 2017;7:45624.