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Pharyngeal Polysaccharide Deacetylases Affect Development in the Nematode C. elegans and Deacetylate Chitin In Vitro

Ronald J. Heustis, Hong K. Ng, Kenneth J. Brand, Meredith C. Rogers, Linda T. Le, Charles A. Specht, Juliet A. Fuhrman

PLoS One. 2012; 7(7): e40426. Published online 2012 Jul 13. doi: 10.1371/journal.pone.0040426

PMCID:: PMC3396651

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Deacetylation of Transcription Factors in Carcinogenesis

Marta Halasa, Kamila Adamczuk, Grzegorz Adamczuk, Syeda Afshan, Andrzej Stepulak, Marek Cybulski, Anna Wawruszak

Int J Mol Sci. 2021 Nov; 22(21): 11810. Published online 2021 Oct 30. doi: 10.3390/ijms222111810

PMCID:: PMC8583941

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Histone deacetylase HDA6 enhances brassinosteroid signaling by inhibiting the BIN2 kinase

Yuhan Hao, Haijiao Wang, Shenglong Qiao, Linna Leng, Xuelu Wang

Proc Natl Acad Sci U S A. 2016 Sep 13; 113(37): 10418–10423. Published online 2016 Aug 25. doi: 10.1073/pnas.1521363113

PMCID:: PMC5027435

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Insights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins

Philipp Knyphausen, Susanne de Boor, Nora Kuhlmann, Lukas Scislowski, Antje Extra, Linda Baldus, Magdalena Schacherl, Ulrich Baumann, Ines Neundorf, Michael Lammers

J Biol Chem. 2016 Jul 8; 291(28): 14677–14694. Published online 2016 May 18. doi: 10.1074/jbc.M116.726307

PMCID:: PMC4938187

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Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43

Jorge Garcia Morato, Friederike Hans, Felix von Zweydorf, Regina Feederle, Simon J. Elsässer, Angelos A. Skodras, Christian Johannes Gloeckner, Emanuele Buratti, Manuela Neumann, Philipp J. Kahle

Nat Commun. 2022; 13: 1223. Published online 2022 Mar 9. doi: 10.1038/s41467-022-28822-7

PMCID:: PMC8907366

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Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway

Peng Wang, Cuicui Yang, Jinhong Lu, Yongxin Ren, David Goltzman, Dengshun Miao

J Orthop Translat. 2023 May; 40: 13–26. Published online 2023 May 5. doi: 10.1016/j.jot.2023.04.003

PMCID:: PMC10185703

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HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1

Tushar K. Ghosh, José J. Aparicio-Sánchez, Sarah Buxton, J. David Brook

Sci Rep. 2019; 9: 17992. Published online 2019 Nov 29. doi: 10.1038/s41598-019-54312-w

PMCID:: PMC6884511

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Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity

Lin Hu, Fuxian Chen, Chao Wu, Jun Wang, Si-si Chen, Xiang-rong Li, Jing Wang, Linpeng Wu, Jian-ping Ding, Jian-chuan Wang, Chao Huang, Hui Zheng, Yu Rao, Yu Sun, Zhijie Chang, Wei Deng, Cheng Luo, Y. Eugene Chin

iScience. 2021 Nov 19; 24(11): 103177. Published online 2021 Sep 27. doi: 10.1016/j.isci.2021.103177

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Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress

H Yang, B Yan, D Liao, S Huang, Y Qiu

Cell Death Dis. 2015 May; 6(5): e1747. Published online 2015 May 7. doi: 10.1038/cddis.2015.106

PMCID:: PMC4669686

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NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation

Meilin Hu, Liangyu Xing, Li Zhang, Fan Liu, Sheng Wang, Ying Xie, Jingjing Wang, Hongmei Jiang, Jing Guo, Xin Li, Jingya Wang, Lei Sui, Changyi Li, Dayong Liu, Zhiqiang Liu

Aging Cell. 2022 Feb; 21(2): e13551. Published online 2022 Jan 15. doi: 10.1111/acel.13551

PMCID:: PMC8844120

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A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

Christian A. Hassig, Jeffrey K. Tong, Tracey C. Fleischer, Takashi Owa, Phyllis G. Grable, Donald E. Ayer, Stuart L. Schreiber

Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7): 3519–3524. doi: 10.1073/pnas.95.7.3519

PMCID:: PMC19868

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Omega-3 Polyunsaturated Fatty Acids Antagonize Macrophage Inflammation via Activation of AMPK/SIRT1 Pathway

Bingzhong Xue, Zhenggang Yang, Xianfeng Wang, Hang Shi

PLoS One. 2012; 7(10): e45990. Published online 2012 Oct 5. doi: 10.1371/journal.pone.0045990

PMCID:: PMC3465287

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An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α

Brian J. Wilson, Annie M. Tremblay, Geneviève Deblois, Guillaume Sylvain-Drolet, Vincent Giguère

Mol Endocrinol. July 1, 2010; 24(7): 1349–1358. doi: 10.1210/me.2009-0441

PMCID:: PMC5417470

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Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1

Zhenggang Yang, Barbara B. Kahn, Hang Shi, Bing-zhong Xue

J Biol Chem. 2010 Jun 18; 285(25): 19051–19059. Published online 2010 Apr 26. doi: 10.1074/jbc.M110.123620

PMCID:: PMC2885183

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Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus

Jie Wang(a), Shudong Wang, Jie Wang(b), Mengjie Xiao, Yuanfang Guo, Yufeng Tang, Jingjing Zhang, Junlian Gu

Front Endocrinol (Lausanne) 2020; 11: 598012. Published online 2021 Jan 18. doi: 10.3389/fendo.2020.598012

PMCID:: PMC7848207

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Nutritional stress-induced regulation of microtubule organization and mRNP transport by HDAC1 controlled α-tubulin acetylation

Frank Wippich, Vaishali, Marco L. Hennrich, Anne Ephrussi

Commun Biol. 2023; 6: 776. Published online 2023 Jul 25. doi: 10.1038/s42003-023-05138-w

PMCID:: PMC10368696

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The TORC1 activates Rpd3L complex to deacetylate Ino80 and H2A.Z and repress autophagy

Xin Li, Qianyun Mei, Qi Yu, Min Wang, Fei He, Duncheng Xiao, Huan Liu, Feng Ge, Xilan Yu, Shanshan Li

Sci Adv. 2023 Mar; 9(10): eade8312. Published online 2023 Mar 8. doi: 10.1126/sciadv.ade8312

PMCID:: PMC9995077

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c-Myc Targets HDAC3 to Suppress NKG2DL Expression and Innate Immune Response in N-Type SCLC through Histone Deacetylation

Peiyan Zhao, Xiaodan Sun, Hui Li, Yan Liu, Yanan Cui, Lin Tian, Ying Cheng

Cancers (Basel) 2022 Feb; 14(3): 457. Published online 2022 Jan 18. doi: 10.3390/cancers14030457

PMCID:: PMC8833590

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The Role of Sirtuins in Antioxidant and Redox Signaling

Chandra K. Singh, Gagan Chhabra, Mary Ann Ndiaye, Liz Mariely Garcia-Peterson, Nicholas J. Mack, Nihal Ahmad

Antioxid Redox Signal. 2018 Mar 10; 28(8): 643–661. Published online 2018 Mar 10. doi: 10.1089/ars.2017.7290

PMCID:: PMC5824489

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Histone H4-Specific Deacetylation at Active Coding Regions by Hda1C

Min Kyung Lee, TaeSoo Kim

Mol Cells. 2020 Oct 31; 43(10): 841–847. Published online 2020 Sep 10. doi: 10.14348/molcells.2020.0141

PMCID:: PMC7604025

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Did you mean: deacetylated (15713 items)

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PMC Images search for deacetylate【有化】

Figure 3Human CBP/p300 acetylates H3 K56 while SirT1 and SirT2 deacetylate H3 K56Ac

a. Levels of H3 K56Ac on human chromatin following gamma irradiation. b. H3 K56Ac localizes to DNA damage foci. c. HU, MMS and UV induce H3 K56Ac. d. CBP/p300 are required for acetylation of H3 K56 in the absence and presence, e, of DNA damage. f. Human CBP and p300, g, acetylate H3 K56 in vitro. h. Inhibition of NAD-dependent HDACs increases H3 K56Ac levels. i. Human SirT2 and SirT1 deacetylate H3 K56Ac in vivo. j. Human SirT2 and SirT1 deacetylate H3 K56Ac in vitro.

CBP / p300-mediated acetylation of histone H3 on lysine 56

Nature. ;459(7243):113-117.
Figure

A Sir2 homologue can deacetylate a metabolic enzyme.
Starai/AAAS

Bacterial aging

J Cell Biol. 2003 Feb 3;160(3):286-286.
Figure 5Soluble extracts of mixed-stage N2 worms deacetylate chitin in vitro.

C. elegans soluble extract (14 µg total protein per lane) was denatured at 80°C and separated by SDS-PAGE under reducing and non-reducing conditions. Proteins were renatured for 24 hours at RT, enabling enzymes to act on glycol chitin embedded within the gel. Gels were stained with calcoflour. Hyperfluorescent bands mark zones where chitosan was produced. (Image is black/white reversed).

Pharyngeal Polysaccharide Deacetylases Affect Development in the Nematode C. elegans and Deacetylate Chitin In Vitro

PLoS One. 2012;7(7):e40426.
Figure 1

Sirtuins regulates multiple aspects of transcription. SIRT1 can deacetylate transcription factors (TF) and regulate their functions by altering their sub-cellular location, changing their expression level, altering their binding to DNA and changing their interactions with regulatory proteins. SIRT1 can also directly deacetylate co-repressor or co-activator, histone and interact with chromatin remodeling proteins to regulate transcription.

Transcription Regulation by Class III Histone Deacetylases (HDACs)—Sirtuins

Transl Oncogenomics. 2008;3:53-65.